Actively Recruiting
MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation
Led by Ottawa Heart Institute Research Corporation · Updated on 2026-05-06
576
Participants Needed
5
Research Sites
268 weeks
Total Duration
On this page
Sponsors
O
Ottawa Heart Institute Research Corporation
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Cardiac allograft vasculopathy (CAV) is a common complication affecting heart transplant patients. This condition causes narrowing of the heart arteries leading to graft dysfunction. Surveillance for CAV is vital; however an ideal approach has not been established. The goal of this study is to assess whether noninvasive positron emission tomography (PET) based surveillance is non-inferior to invasive coronary angiography (ICA) surveillance.
CONDITIONS
Official Title
MARINER Trial: Multiparametric Cardiac PET for CAV Surveillance After Heart Transplantation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Post heart transplant between 2 and 10 years
- Age 18 years or older
- Able to provide informed consent
You will not qualify if you...
- Severe aortic stenosis preventing dipyridamole use
- 2:1 or greater AV block without pacemaker preventing dipyridamole use
- Severe bronchospasm preventing dipyridamole use
- Allergy to iodinated contrast preventing coronary angiography
- Glomerular filtration rate 30 mL/min/1.73 m2 or less for non-dialysis patients preventing coronary angiography
- Unsuitable vascular access preventing coronary angiography
- Treated rejection within the past month
- Unstable angina or myocardial infarction within the past 7 days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 5 locations
1
University of Calgary
Calgary, Alberta, Canada
Not Yet Recruiting
2
Mazankowski Alberta Heart Institute
Edmonton, Alberta, Canada
Not Yet Recruiting
3
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Actively Recruiting
4
Toronto-General Hospital - University Health Network
Toronto, Ontario, Canada
Not Yet Recruiting
5
Montreal Heart Institute
Montreal, Quebec, Canada
Not Yet Recruiting
Research Team
S
Sharon Chih
CONTACT
H
Heather Ross
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here