Actively Recruiting
MASCoD - Multidimensional Assessment of Subjective Cognitive Decline
Led by Istituti Clinici Scientifici Maugeri SpA · Updated on 2025-05-08
100
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Subjective cognitive decline-SCD is a subclinical cognitive impairment subjectively experienced without being detectable from a diagnostic and neuropsychological perspective. It can negatively impact on patient's frailty and quality of life and it may be prodromal to severe cognitive impairment. Currently, only a few screening tools focusing mainly on memory complaints exist. The aim of this study is to analyze if a new screening tool called MASCoD (Multidimensional Assessment of Subjective Cognitive Decline) can detect and monitor the SCD, predicting the risk of developing severe cognitive decline over time. Specifically, the investigators have the following aims: primary objectives: 1. To assess the construct validity and tune the clinical cutoffs of the new instrument through the correlation of MASCoD scores with neuropsychological evaluation and brain 18F-FDG-PET. 2. To assess the clinical validity (predictive capability) of the new instrument through a classification model (dependent variable: brain 18F-FDG-PET examination; independent variable: MASCoD; control variables: gender, age and neuropsychological evaluation). Secondary objective: To evaluate the suitability of MASCoD as tool for the monitoring of patients over time. Specifically, the investigators want to evaluate if the MASCoD score is able to assess the effects of a cognitive treatment and, in turn, to identify outpatients who most likely will benefit from it. After the multidimensional evaluation at T0, the participants will be randomly allocated into an experimental group and a wait list control group. Specifically, cognitive training will be offered by means of technological devices (Neurotablet). At T1, all outpatients (experimental group and wait list control group) will be evaluated through MASCoD and the extensive neuropsychological evaluation for the second time.
CONDITIONS
Official Title
MASCoD - Multidimensional Assessment of Subjective Cognitive Decline
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Reported subjective cognitive decline without other cognitive or neurological issues
- Italian education
- Adults over 55 years old
- Understanding of research aims
- Signed informed consent
- Participation on a voluntary and unpaid basis
You will not qualify if you...
- Serious clinical conditions such as severe cardiac or respiratory problems, or cancer
- Prior diagnosis of psychiatric disorders according to DSM-5
- Prior diagnosis of cognitive decline
- Significant vision or hearing deficits
- Illiteracy or relapse in illiteracy
- Refusal to participate in the research
AI-Screening
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Trial Site Locations
Total: 1 location
1
ICS Maugeri Montescano Institute
Montescano, Pavia, Italy, 27040
Actively Recruiting
Research Team
C
Cira Fundarò, Neurologist
CONTACT
M
Marina Maffoni, Psychologist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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