Actively Recruiting
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Led by Veterans Medical Research Foundation · Updated on 2025-04-22
200
Participants Needed
4
Research Sites
152 weeks
Total Duration
On this page
Sponsors
V
Veterans Medical Research Foundation
Lead Sponsor
U
University of Minnesota
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.
CONDITIONS
Official Title
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans
- Age 18 years or older
- Veterans who served since September 2001
- Currently enrolled in an intensive outpatient substance use treatment program at a participating VA
- Meet DSM-5 criteria for a current substance use disorder (excluding tobacco use disorder alone)
- Meet DSM-5 criteria for post-traumatic stress disorder (PTSD)
- Report substance use on at least 20 of the last 90 days
- Able to provide informed consent
You will not qualify if you...
- Severe cognitive impairment
- Current suicidal or homicidal intent that requires immediate treatment
- Current unstable psychotic or manic symptoms not related to substance use disorder
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 4 locations
1
VA San Diego Healthcare System
San Diego, California, United States, 92161
Actively Recruiting
2
VA Tampa Healthcare System
Tampa, Florida, United States, 33612
Actively Recruiting
3
VA Atlanta Healthcare System
Atlanta, Georgia, United States, 30033
Actively Recruiting
4
Hines VA Healthcare System
Chicago, Illinois, United States, 60141
Actively Recruiting
Research Team
S
Sonya Norman, PhD
CONTACT
K
Kaitlyn Panza, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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