Actively Recruiting
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
Led by Philip Spinella · Updated on 2026-05-11
1000
Participants Needed
23
Research Sites
204 weeks
Total Duration
On this page
Sponsors
P
Philip Spinella
Lead Sponsor
B
Biomedical Advanced Research and Development Authority
Collaborating Sponsor
AI-Summary
What this Trial Is About
The MATIC-2 is a multicenter clinical trial enrolling children who are less than 18 years of age with hemorrhagic shock potentially needing significant blood transfusion. The primary objective of the clinical trial is to determine the effectiveness of Low Titer Group O Whole Blood (LTOWB) compared to component therapy (CT), and Tranexamic Acid (TXA) compared to placebo in decreasing 24-hour all-cause mortality in children with traumatic life threatening hemorrhage.
CONDITIONS
Official Title
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children less than 18 years old with traumatic injury
- Massive transfusion protocol activation for confirmed or suspected life-threatening traumatic bleeding
- Active bleeding with at least two of the following: low blood pressure for age, high heart rate for age, or exam findings indicating severe bleeding (such as penetrating injury, hemothorax, bruised swollen abdomen, or limb amputation)
You will not qualify if you...
- Devastating traumatic brain injury not expected to survive (e.g., severe brain injury with fixed pupils)
- Massive transfusion protocol activated but no blood products given
- Received emergency thoracotomy or more than 5 minutes of CPR before blood products
- Known or suspected pregnancy
- Known prisoners
- Ward of the state
- Isolated hanging, drowning, or burns
- Previous enrollment in this trial
- Previously opted out of the study
- Prehospital or prior use of Tranexamic Acid
- More than 3 hours since injury
- History of seizures after injury
- Allergy or hypersensitivity to Tranexamic Acid
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 23 locations
1
University of Arizona
Tucson, Arizona, United States, 84719
Actively Recruiting
2
Arkansas Children's Hospital
Little Rock, Arkansas, United States, 72202
Actively Recruiting
3
University of California Davis
Sacramento, California, United States, 95817
Actively Recruiting
4
Children's National Hospital
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
5
Emory University-Arthur M. Blank Hospital
Atlanta, Georgia, United States, 30329
Actively Recruiting
6
Emory University-Scottish Rite Hospital
Atlanta, Georgia, United States, 30342
Actively Recruiting
7
Tulane School of Medicine
New Orleans, Louisiana, United States, 70118
Actively Recruiting
8
University of Mississippi Medical Center
Jackson, Mississippi, United States, 39216
Actively Recruiting
9
Washington University of St. Louis
St Louis, Missouri, United States, 63110
Actively Recruiting
10
University of New Mexico
Albuquerque, New Mexico, United States, 87131
Actively Recruiting
11
Wake Forest University Health Sciences
Wake Forest, North Carolina, United States, 27157
Actively Recruiting
12
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
13
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
14
Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
15
LeBonheur Children's Hospital
Memphis, Tennessee, United States, 38103
Actively Recruiting
16
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Not Yet Recruiting
17
The University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
18
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
19
Children's Memorial Hermann Hospital
Houston, Texas, United States, 77030
Actively Recruiting
20
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
21
Primary Children's Hospital
Salt Lake City, Utah, United States, 84112
Actively Recruiting
22
University of Washington Harborview
Seattle, Washington, United States, 98195
Actively Recruiting
23
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
Research Team
J
Jane Luce
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
4
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