Actively Recruiting
A Master Protocol Empowering Mechanobiology Translation Research in Breast Cancer
Led by IFOM ETS - The AIRC Institute of Molecular Oncology · Updated on 2025-05-01
1500
Participants Needed
10
Research Sites
332 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
METAMECH is a master observational protocol designed to empower a bi-directional collaboration between basic and clinical research, an essential prerequisite to feed and implement precision oncology. METAMECH will follow a stage-mixed cohort of at least 500 patients through their course of treatments, until death or a minimum of 5 years. Patients will be longitudinally sampled and matched clinical data (including imaging) will be collected. Via a multi-tiered informed consensus process, METAMECH will also allow to develop companion diagnostics for molecular enrichment strategies in AIRC-driven proof-of-concept trials.
CONDITIONS
Official Title
A Master Protocol Empowering Mechanobiology Translation Research in Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 18 years or older
- Previous diagnosis or strong suspicion of breast cancer based on clinical and radiological findings
- ECOG Performance status less than 2 (for TIER1 and TIER2 participants)
- Either unable to be reached for consent per national regulations or has provided written informed consent for TIER1
You will not qualify if you...
- Current malignancy or malignancy diagnosed or relapsed within past 5 years, except non-melanomatous skin cancer, stage 0 melanoma in situ, or in situ cervical cancer
- Unable to comply with study protocol due to psychological, social, or geographical reasons
- Known infection with HIV, Hepatitis B Virus, Hepatitis C Virus, or syphilis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Asst Papa Giovanni Xxiii
Bergamo, Bergamo, Italy, 24127
Not Yet Recruiting
2
Fondazione IRCCS, Istituto Nazionale dei Tumori
Milan, Milan, Italy, 20133
Actively Recruiting
3
Fondazione IRCCS, Istituto Neurologico Carlo Besta
Milan, Milan, Italy, 20133
Actively Recruiting
4
Azienda Ospedaliero Universitaria Maggiore della Carità di Novara
Novara, Novara, Italy, 28100
Actively Recruiting
5
Istituto Oncologico Veneto IRCCS (IOV)
Padova, Padova, Italy, 35128
Actively Recruiting
6
Fondazione IRCCS, Policlinico San Matteo Pavia
Pavia, Pavia, Italy, 27100
Actively Recruiting
7
Istituto Nazionale Tumori Regina Elena di Roma - Istituti Fisioterapici Ospitalieri (IFO)
Roma, Roma, Italy, 00144
Actively Recruiting
8
IRCCS Humanitas
Milan, Italy, 20089
Actively Recruiting
9
IEO - Istituto Europeo di Oncologia
Milan, Italy, 20141
Actively Recruiting
10
Azienda U.S.L. - IRCCS di Reggio Emilia
Reggio Emilia, Italy, 42122
Actively Recruiting
Research Team
S
Smeralda Rapisarda
CONTACT
Y
Ylenia Silvestri, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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