Observational Study of Mechanobiology in Breast Cancer Patients Tracking Tumor Evolution and Treatment Outcomes Including Long-Term Data and Sample Collection

What this Trial Is About

Researchers are conducting an observational study called METAMECH focused on breast cancer patients. This study aims to enhance collaboration between basic and clinical research to support precision oncology by understanding how tumor and host cells evolve together. The goal is to improve patient outcomes, such as reducing the chance of cancer recurrence and improving survival, by collecting clinical data and samples over time. The study will include at least 500 breast cancer patients at various stages, following them through their treatments until death or for a minimum of five years. Patients will be enrolled at two key points before tumor sampling such as surgery or biopsy or before starting any new treatment. METAMECH is organized into tiers to manage data and samples, including retrospective and prospective collection, experimental modeling, and linking data with proof-of-concept trials targeting tumor mechanisms. Participants will be regularly monitored with clinical data collection, imaging, and biological sampling. The study will track the number of patients recruited in different tiers every six months and the number triaged into experimental trials. This long-term observation aims to generate insights into breast cancer progression and support the development of new diagnostic and treatment strategies. The study is designed to be flexible to allow comprehensive data capture throughout the patients treatment journey.

A Master Protocol Empowering Mechanobiology Translation Research in Breast Cancer