Actively Recruiting
CAMPFIRE: Children's and Young Adult Master Protocol for Innovative Pediatric Cancer Research
Led by Eli Lilly and Company · Updated on 2026-03-27
105
Participants Needed
73
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are conducting a master protocol study to streamline several clinical trials testing different drugs in children and young adults with various cancers. This master protocol allows multiple cancer-specific studies to be added over time as new drugs become available. Participation depends on how long the treatment benefits last. The study is sponsored by Eli Lilly and Company and focuses on patients aged 1 to 39 years with measurable or evaluable cancer. The study evaluates multiple treatment combinations for specific cancer types. For desmoplastic small round cell tumor (DSRCT), participants may receive ramucirumab intravenously with oral cyclophosphamide and intravenous vinorelbine in 28-day cycles or cyclophosphamide and vinorelbine without ramucirumab. For synovial sarcoma (SS), treatment options include ramucirumab with gemcitabine intravenously or gemcitabine with docetaxel intravenously in 21-day cycles. For Ewing's sarcoma (ES), participants may receive abemaciclib orally with intravenous irinotecan and oral temozolomide or irinotecan with temozolomide alone, also in 21-day cycles. Treatments are given according to randomized assignment without masking. Participants are monitored from baseline through the first four weeks to track allocation to each treatment group. Eligibility requires certain performance scores and recovery from prior cancer treatments, along with adequate organ function. Female participants of childbearing potential must have a negative pregnancy test and agree to use contraception. Throughout the study, medical history, disease assessments, and safety monitoring are conducted to evaluate treatment effects. The study is planned to continue until May 2027, allowing for long-term observation and data collection.
CONDITIONS
Brief Title
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Measurable or evaluable cancer using standard methods (RECIST 1.1)
- Lansky performance score of at least 50 for participants under 16 years
- Karnofsky performance score of at least 50 for participants 16 years or older
- Discontinued all previous cancer treatments or investigational agents at least 7 days before start
- Recovered from clinically significant side effects of prior treatments
- Adequate blood and organ function
- Negative pregnancy test within 7 days before first dose for females of childbearing potential
- Agreement to use effective contraception during the trial and for at least 3 months after the last dose for participants of childbearing potential
You will not qualify if you...
- Severe or uncontrolled medical or psychiatric conditions that may cause safety risks or affect protocol compliance
- Active infections requiring therapy
- Prior allogeneic bone marrow or solid organ transplant
- Planned or recent invasive procedures as defined by the protocol
- Pregnancy or breastfeeding in female participants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 28-day or 21-day cycles depending on treatment arm
Participants receive assigned drug regimens in cycles depending on their specific cancer type, including intravenous and oral medications.
Visits every cycle for treatment administration and monitoring
Trial Site Locations
Total: 73 locations
1
Childrens Hospital of Alabama
Birmingham, Alabama, United States, 35233
Not Yet Recruiting
2
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
3
Phoenix Children's Hospital
Phoenix, Arizona, United States, 85016
Actively Recruiting
4
Childrens Hospital of Los Angeles
Los Angeles, California, United States, 90027
Completed
5
UCLA Medical Center
Los Angeles, California, United States, 90095
Not Yet Recruiting
6
Children's Hospital of Orange County
Orange, California, United States, 92868
Actively Recruiting
7
Children's Hospital of Colorado
Denver, Colorado, United States, 80218
Actively Recruiting
8
Children's National Medical Center
Washington D.C., District of Columbia, United States, 20010
Actively Recruiting
9
Golisano Children's Hospital of Southwest Florida
Fort Myers, Florida, United States, 33908
Actively Recruiting
10
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
Actively Recruiting
11
Children's Healthcare of Atlanta, Inc. at Egleston
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
12
Ann & Robert H Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
13
Riley Hospital for Children
Indianapolis, Indiana, United States, 46202-5225
Active, Not Recruiting
14
Dana-Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
15
C.S. Mott Children's Hospital
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
16
University of Minnesota Hospital
Minneapolis, Minnesota, United States, 55455
Not Yet Recruiting
17
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108
Actively Recruiting
18
Washington University Medical School
St Louis, Missouri, United States, 63110
Completed
19
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
20
Nationwide Children's Hosp
Columbus, Ohio, United States, 43205-2664
Actively Recruiting
21
Oregon Health and Science University
Portland, Oregon, United States, 97201
Not Yet Recruiting
22
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Completed
23
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
24
Lifespan Cancer Institute
Providence, Rhode Island, United States, 02906
Actively Recruiting
25
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75390-9063
Actively Recruiting
26
Cook Children's Hospital
Fort Worth, Texas, United States, 76104-2724
Active, Not Recruiting
27
Texas Childrens Hospital
Houston, Texas, United States, 77025
Not Yet Recruiting
28
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
29
Seattle Children's Hospital Research Foundation
Seattle, Washington, United States, 98105
Actively Recruiting
30
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
Not Yet Recruiting
31
Chris O'Brien Lifehouse
Camperdown, Australia, 2050
Actively Recruiting
32
Peter MacCallum Cancer Centre
Melbourne, Australia, 3000
Actively Recruiting
33
Royal Children's Hospital
Melbourne, Australia, 3052
Actively Recruiting
34
The Sydney Children's Hospitals Network
Westmead, Australia, 2145
Not Yet Recruiting
35
UCL- Saint Luc
Brussels, Belgium, 1200
Actively Recruiting
36
Universitair Ziekenhuis Gent
Ghent, Belgium, 9000
Completed
37
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, France, 33076
Actively Recruiting
38
Centre Leon Berard
Lyon, France, 69008
Not Yet Recruiting
39
Centre Leon Berard
Lyon, France, 69008
Actively Recruiting
40
Institut Curie
Paris, France, 75248
Not Yet Recruiting
41
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
42
Universitaetsklinikum Freiburg
Freiburg im Breisgau, Germany, 79106
Actively Recruiting
43
Universitaetsklinikum Hamburg-Eppendorf
Hamburg, Germany, 20251
Actively Recruiting
44
IRCCS Istituto Ortopedico Rizzoli
Bologna, Italy, 40136
Actively Recruiting
45
Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia
Candiolo, Italy, 10060
Actively Recruiting
46
Istituto Nazionale dei Tumori
Milan, Italy, 20133
Actively Recruiting
47
Azienda Ospedaliera Di Padova
Padova, Italy, 35128
Actively Recruiting
48
Ospedale Bambino Gesu
Roma, Italy, 00165
Actively Recruiting
49
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore
Roma, Italy, 00168
Actively Recruiting
50
Istituto Clinico Humanitas
Rozzano, Italy, 20089
Actively Recruiting
51
National Cancer Center Hospital
Chūōku, Japan, 104-0045
Actively Recruiting
52
Kyushu University Hospital
Fukuoka, Japan, 812-8582
Actively Recruiting
53
Hyogo Prefectural Kobe Children's Hospital
Kobe, Japan, 650-0047
Actively Recruiting
54
Leids Universitair Medisch Centrum
Leiden, Netherlands, 2333 ZA
Actively Recruiting
55
Prinses Maxima Centrum
Utrecht, Netherlands, 3584 CS
Actively Recruiting
56
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain, 08025
Actively Recruiting
57
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
58
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 8035
Actively Recruiting
59
Hospital Sant Joan de Déu
Esplugues de Llobregat, Spain, 8950
Actively Recruiting
60
Hospital General Universitario Gregorio Marañon
Madrid, Spain, 28007
Actively Recruiting
61
Hospital General Universitario Gregorio Marañon
Madrid, Spain, 28007
Actively Recruiting
62
Hospital Infantil Universitario Niño Jesús
Madrid, Spain, 28009
Actively Recruiting
63
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
64
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
65
Hospital Universitario de Canarias
San Cristóbal de La Laguna, Spain, 38320
Actively Recruiting
66
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
67
Hospital Universitario Virgen Del Rocio
Seville, Spain, 41013
Actively Recruiting
68
Hospital Universitari i Politecnic La Fe
Valencia, Spain, 46026
Actively Recruiting
69
University College Hospital - London
London, United Kingdom, NW1 2PG
Actively Recruiting
70
Royal Marsden Hospital
London, United Kingdom, SW3 6JJ
Actively Recruiting
71
Royal Marsden Hospital
London, United Kingdom, SW3 6JJ
Actively Recruiting
72
Royal Manchester Children's Hospital
Manchester, United Kingdom, M13 9WL
Actively Recruiting
73
The Christie NHS Foundation Trust
Manchester, United Kingdom, M20 4BX
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
P
Physicians interested in becoming principal investigators please contact
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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