Actively Recruiting
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
Led by Eli Lilly and Company · Updated on 2026-05-12
974
Participants Needed
100
Research Sites
122 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.
CONDITIONS
Official Title
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has systolic blood pressure (SBP) 140 mmHg and/or diastolic blood pressure (DBP) 90 mmHg (if DBP criteria alone is met, SBP must be 130 mmHg) at screening (Visit 1)
- Has SBP 140 mmHg and/or DBP 90 mmHg (if DBP criteria alone is met, SBP must be 130 mmHg) at week 0 (Visit 3)
- Untreated for hypertension, or on stable antihypertensive medications 30 days prior to Visit 1
- Have a body mass index (BMI) 25 kg/m8
You will not qualify if you...
- Has SBP 170 mmHg and/or DBP 110 mmHg at Visit 1 or at Visit 3
- Has known secondary causes of hypertension
- Have heart failure with reduced ejection fraction (HFrEF) diagnosis
- Have had hospitalization for hypertension or for congestive heart failure within 90 days prior to screening
- Have had acute coronary syndrome or acute myocardial infarction within 90 days prior to screening
- Have had cerebrovascular accident (stroke) within 90 days prior to screening
- Have type 1 diabetes (T1D)
- Have acute or chronic hepatitis, including a history of autoimmune hepatitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 100 locations
1
Elite Clinical Studies, LLC
Phoenix, Arizona, United States, 85018
Active, Not Recruiting
2
Valley Clinical Trials, Inc.
Covina, California, United States, 91723
Active, Not Recruiting
3
Valley Clinical Trials, Inc.
Northridge, California, United States, 91325
Active, Not Recruiting
4
Chase Medical Research, LLC
Waterbury, Connecticut, United States, 06708
Active, Not Recruiting
5
Excel Medical Clinical Trials
Boca Raton, Florida, United States, 33434
Active, Not Recruiting
6
Care Access - Brandon
Brandon, Florida, United States, 33510
Active, Not Recruiting
7
Northeast Research Institute - Downtown Office
Jacksonville, Florida, United States, 32204
Active, Not Recruiting
8
Care Access - St. Petersburg
St. Petersburg, Florida, United States, 33710
Completed
9
East-West Medical Research Institute
Honolulu, Hawaii, United States, 96814
Active, Not Recruiting
10
Sinai Hospital Of Baltimore
Baltimore, Maryland, United States, 21209
Active, Not Recruiting
11
Ascension Saint Agnes Heart Care
Baltimore, Maryland, United States, 21229
Active, Not Recruiting
12
Lucida Clinical Trials
New Bedford, Massachusetts, United States, 02740
Active, Not Recruiting
13
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States, 48098
Active, Not Recruiting
14
StudyMetrix Research
City of Saint Peters, Missouri, United States, 63303
Active, Not Recruiting
15
Excel Clinical Research, LLC
Las Vegas, Nevada, United States, 89109
Active, Not Recruiting
16
Palm Research Center Sunset
Las Vegas, Nevada, United States, 89148
Active, Not Recruiting
17
Rochester Clinical Research, LLC
Rochester, New York, United States, 14609
Active, Not Recruiting
18
Remington-Davis, Inc
Columbus, Ohio, United States, 43215
Active, Not Recruiting
19
PriMED Clinical Research
Dayton, Ohio, United States, 45429
Active, Not Recruiting
20
Advanced Research Institute - Tigard
Tigard, Oregon, United States, 97223
Active, Not Recruiting
21
Care Access - Mauldin
Mauldin, South Carolina, United States, 29662
Active, Not Recruiting
22
Dallas Heart and Vascular Consultants, PA
Duncanville, Texas, United States, 75137
Active, Not Recruiting
23
Texas Institute of Cardiology, PA
McKinney, Texas, United States, 75071
Active, Not Recruiting
24
North Hills Family Medicine/North Hills Medical Research
North Richland Hills, Texas, United States, 76180
Active, Not Recruiting
25
Advanced Research Institute
Ogden, Utah, United States, 84405
Active, Not Recruiting
26
Carient Heart & Vascular - Manassas
Manassas, Virginia, United States, 20109
Active, Not Recruiting
27
Health Research of Hampton Roads, Inc.
Newport News, Virginia, United States, 23606
Active, Not Recruiting
28
National Clinical Research, Inc
Richmond, Virginia, United States, 23294
Active, Not Recruiting
29
Eastside Research Associates
Redmond, Washington, United States, 98052
Active, Not Recruiting
30
Instituto Médico Especializado (IME)
Buenos Aires, Argentina, 1405
Active, Not Recruiting
31
CIPREC
Buenos Aires, Argentina, C1061AAS
Active, Not Recruiting
32
CIPREC
Buenos Aires, Argentina, C1119ACN
Active, Not Recruiting
33
CEMEDIC
Buenos Aires, Argentina, C1407GTN
Active, Not Recruiting
34
Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina, 5000
Active, Not Recruiting
35
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Argentina, 2152
Active, Not Recruiting
36
INECO Neurociencias Oroño
Rosario, Argentina, 2000
Active, Not Recruiting
37
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, Argentina, 2000
Active, Not Recruiting
38
Santa Maria de la Salud Centro Medico
San Isidro, Argentina, 1642
Active, Not Recruiting
39
Beijing Pinggu District Hospital
Beijing, China, 101200
Active, Not Recruiting
40
China-Japan Union Hospital
Changchun, China, 130033
Active, Not Recruiting
41
Changde First People's Hospital
Changde, China, 415000
Active, Not Recruiting
42
Sichuan Provincial People's Hospital
Chengdu, China, 610072
Active, Not Recruiting
43
The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus
Chongqing, China, 400010
Active, Not Recruiting
44
Jinan Central Hospital
Jinan, China, 250013
Active, Not Recruiting
45
Lishui Central Hospital
Lishui, China
Active, Not Recruiting
46
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, China, 471003
Active, Not Recruiting
47
Ruijin Hospital Shanghai Jiaotong University School of Medicine
Shanghai, China, 200001
Active, Not Recruiting
48
Siping Central People's Hospital
Siping, China, 136000
Active, Not Recruiting
49
Wuxi People's Hospital
Wuxi, China, 214023
Active, Not Recruiting
50
Shaanxi provincial people's hospital
Xi'an, China, 710068
Active, Not Recruiting
51
Top Moravia Health
Brno, Czechia, 61500
Active, Not Recruiting
52
Ordinace Rihackovi, s.r.o.
Brno, Czechia, 641 00
Active, Not Recruiting
53
CTC Hodonin s.r.o.
Hodonín, Czechia, 695 01
Active, Not Recruiting
54
MUDr. Sarka Drinkova
Ledeč nad Sázavou, Czechia, 584 01
Active, Not Recruiting
55
CCR Ostrava s.r.o
Ostrava, Czechia, 702 00
Active, Not Recruiting
56
Diahelp s.r.o
Pardubice V, Czechia, 530 02
Active, Not Recruiting
57
Clinoxus
Prague, Czechia, 140 00
Active, Not Recruiting
58
Angiocentrum Komorany
Prague, Czechia, 143 00
Active, Not Recruiting
59
Praglandia s.r.o
Prague, Czechia, 150 00
Active, Not Recruiting
60
Zentrum für klinische Studien Bad Homburg
Bad Homburg, Germany, 61348
Active, Not Recruiting
61
FutureMeds GmbH
Berlin, Germany, 10629
Active, Not Recruiting
62
Zentrum fur klinische Forschung - Köln
Cologne, Germany, 51069
Active, Not Recruiting
63
Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien
Dresden, Germany, 01277
Active, Not Recruiting
64
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Active, Not Recruiting
65
Medizentrum Essen Borbeck
Essen, Germany, 45355
Active, Not Recruiting
66
AmBeNet GmbH
Leipzig, Germany, 04107
Active, Not Recruiting
67
Familienmedizinisches Zentrum Radowsky
Leipzig, Germany, 04179
Active, Not Recruiting
68
RED-Institut GmbH
Oldenburg, Germany, 23758
Active, Not Recruiting
69
Athens Medical Center - Psychikon branch
Athens, Greece, 115 25
Active, Not Recruiting
70
General Hospital of Athens "G. Gennimatas"
Athens, Greece, 11527
Active, Not Recruiting
71
University Hospital of Ioannina
Ioannina, Greece, 45500
Active, Not Recruiting
72
G. Gennimatas General Hospital of Thessaloniki
Thessaloniki, Greece, 546 35
Active, Not Recruiting
73
AHEPA University General Hospital of Thessaloniki
Thessaloniki, Greece, 546 36
Active, Not Recruiting
74
Papageorgiou General Hospital of Thessaloniki
Thessaloniki, Greece, 56403
Active, Not Recruiting
75
Life Care Hospital and Research Centre
Bangalore, India, 560092
Actively Recruiting
76
All India Institute of Medical Sciences
Bhubaneswar, India, 751019
Actively Recruiting
77
G.B. Pant Institute of Postgraduate Medical Education & Research
New Delhi, India, 110002
Actively Recruiting
78
Ashirwad Hospital and Research Centre
Ulhasnagar, India, 421004
Actively Recruiting
79
Tokyo-Eki Center-building Clinic
Chūōku, Japan, 103-0027
Active, Not Recruiting
80
Fukuwa Clinic
Chūōku, Japan, 104-0031
Active, Not Recruiting
81
Takai Internal Medicine Clinic
Kamakura-shi, Japan, 247-0056
Active, Not Recruiting
82
Mikannohana Clinic, Diabetes, Endocrinology and Metabolism
Matsuyama, Japan, 7900034
Active, Not Recruiting
83
Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic
Yamato-shi, Japan, 242-0004
Active, Not Recruiting
84
Uniwersytecki Szpital Kliniczny w Białymstoku
Bialystok, Poland, 15-276
Active, Not Recruiting
85
Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk
Bydgoszcz, Poland, 85-092
Active, Not Recruiting
86
NZOZ Centrum Medyczne KERmed
Bydgoszcz, Poland, 85-231
Active, Not Recruiting
87
IRMED
Piotrkow Trybunalski, Poland, 97-300
Active, Not Recruiting
88
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, Poland, 37-700
Active, Not Recruiting
89
Private Practice - Dr. Robert Witek
Tarnów, Poland, 33-100
Active, Not Recruiting
90
Balsam Medica
Warsaw, Poland, 01-249
Active, Not Recruiting
91
NZOZ Regionalna Poradnia Diabetologiczna
Wroclaw, Poland, 50-127
Active, Not Recruiting
92
Dorado Medical Complex
Dorado, Puerto Rico, 00646
Active, Not Recruiting
93
Puerto Rico Medical Research
Ponce, Puerto Rico, 00717
Active, Not Recruiting
94
CHUAC-Complejo Hospitalario Universitario A Coruña
A Coruña, Spain, 15001
Active, Not Recruiting
95
Hospital San Rafael - La Coruña
A Coruña, Spain, 15006
Active, Not Recruiting
96
EAP Sardenya
Barcelona, Spain, 08025
Active, Not Recruiting
97
EAP Osona Sud - Alt Congost S.L.P
Centelles, Spain, 08540
Active, Not Recruiting
98
Complejo Asistencial Universitario de León - Hospital de León
León, Spain, 24071
Active, Not Recruiting
99
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, Spain, 41003
Active, Not Recruiting
100
Hospital Quiron Infanta Luisa
Seville, Spain, 41010
Active, Not Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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