Maternal and fetal risk factors for stillbirth: population based study.
Jason Gardosi, Vichithranie Madurasinghe, Mandy Williams...
https://pubmed.ncbi.nlm.nih.gov/23349424/Actively Recruiting
Led by University of Colorado, Denver · Updated on 2025-07-17
100
Participants Needed
2
Research Sites
26 weeks
Total Duration
This research aims to evaluate if resting in the maternal left-lateral position can improve fetal growth in pregnancies affected by fetal growth restriction. The study also investigates how this position affects maternal metabolomics, mental health, fetal heart function, and delivery outcomes by comparing women who use the left-lateral position to those receiving standard care without this positioning. Participants will be randomly assigned to one of two groups. One group will practice the left-lateral recumbent position daily for a total of 4 hours with a 10-minute stretching break after each hour, alongside recommendations for mild to moderate exercise 2-3 times per week and a healthy diet for 4 weeks. The other group will continue standard care with similar exercise and diet advice. Both groups will wear a smartwatch to monitor physical activity at home. A follow-up visit will occur 4 weeks after enrollment and again at delivery. Throughout the study, participants will be monitored for fetal growth using fetal biometry scans at 4 weeks, fetal cardiac function, and blood flow measurements. Maternal mental health and metabolomics will be assessed at 4 weeks and delivery. Delivery outcomes will also be recorded. The use of smartwatches will help track adherence to the intervention and physical activity levels. The total study duration for each participant includes 4 weeks of intervention followed by delivery observation.
CONDITIONS
Maternal Left Lateral Position in Fetal Growth Restriction
H
Hannah E Vincent, PhD
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University of Colorado, Denver
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Scheduled left lateral recumbent positioning (with hourly stretching) | Routine maternal positioning (no prescribed positional intervention) |
|---|---|---|
| What it is | Pregnant patients rest in the left lateral recumbent position for up to four hours daily, including intermittent 10-minute stretches each hour. | Participants continue their typical routine positioning during rest, without prescribed changes or enforced bed rest. |
| Role in the trial | This is the active behavioral intervention group under study. | This is the control group receiving routine care practices. |
| Primary use or purpose | Structured left lateral positioning is being evaluated for its impact on fetal growth and well-being in pregnancies complicated by fetal growth restriction. | Continued routine maternal positioning serves as the comparative benchmark, reflecting standard resting practices in current care. |
| How it is given or performed | Pregnant patients maintain a left side-lying position while at rest for up to four hours per day, taking a 10-minute stretch break each hour. | No specific instructions are given; individuals rest in positions of their choosing as per normal practice. |
| Evidence status | Earlier small studies and recent publications suggest maternal rest may improve fetal growth in small-for-gestational-age fetuses, but definitive impacts of structured lateral positioning remain under investigation. | No high-quality evidence supports routine bed rest, prescribed positioning, or activity restriction for fetal growth restriction. Guidelines recommend against routine restriction. |
| Important risks | Prolonged inactivity and scheduled resting, even with intermittent stretching, may carry risks of deconditioning, discomfort, and possibly increased risk of venous thromboembolism. | Usual activity positioning carries minimal risk and is considered safe for most pregnant individuals without contraindication. |
| Important limitations | The actual benefit of structured left lateral positioning on fetal outcomes is uncertain, as most prior studies have focused on bed rest or maternal rest in general, not on specifically timed positions. Adherence may also be challenging for some individuals. | Routine positioning may not address all risk factors for fetal growth restriction and does not represent an active therapeutic intervention. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 4 weeks
Participants practice left-lateral recumbent positioning for a total of 4 hours daily with intermittent stretching, along with mild to moderate intensity exercise 2-3 times per week and a healthy diet. Activity is recorded via a smart watch.
Daily at-home activity tracking with smart watch; periodic clinical visits as per protocol
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Lead Sponsor