ACOG Practice Bulletin No. 204: Fetal Growth Restriction.
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Obstetrics and the Society forMaternal-FetalMedicin
https://pubmed.ncbi.nlm.nih.gov/30681542Actively Recruiting
Phase Not Applicable
Age: 18Years - 65Years
FEMALE
ID06919692
Impact of Maternal Left-Lateral Recumbent Positioning in Pregnancies With Fetal Growth Restriction
Led by University of Colorado, Denver · Updated on 2025-07-17
100
Participants Needed
2
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to evaluate if resting in the maternal left-lateral position can improve fetal growth in pregnancies affected by fetal growth restriction. The study also investigates how this position affects maternal metabolomics, mental health, fetal heart function, and delivery outcomes by comparing women who use the left-lateral position to those receiving standard care without this positioning. Participants will be randomly assigned to one of two groups. One group will practice the left-lateral recumbent position daily for a total of 4 hours with a 10-minute stretching break after each hour, alongside recommendations for mild to moderate exercise 2-3 times per week and a healthy diet for 4 weeks. The other group will continue standard care with similar exercise and diet advice. Both groups will wear a smartwatch to monitor physical activity at home. A follow-up visit will occur 4 weeks after enrollment and again at delivery. Throughout the study, participants will be monitored for fetal growth using fetal biometry scans at 4 weeks, fetal cardiac function, and blood flow measurements. Maternal mental health and metabolomics will be assessed at 4 weeks and delivery. Delivery outcomes will also be recorded. The use of smartwatches will help track adherence to the intervention and physical activity levels. The total study duration for each participant includes 4 weeks of intervention followed by delivery observation.
CONDITIONS
Brief Title
Maternal Left Lateral Position in Fetal Growth Restriction
Who Can Participate
Age: 18Years - 65Years
FEMALE
Eligibility Criteria
You may qualify if you...
- Pregnant persons aged between 18 and 65 years
- Diagnosis of fetal growth restriction with estimated fetal weight below the tenth percentile
- Singleton pregnancy between 24 and 34 weeks gestational age
- Fluency in English or Spanish language
You will not qualify if you...
- History of deep vein thrombosis, pulmonary embolism, or hypercoagulability disorder
- Pre-pregnancy BMI greater than 40
- Severe abnormality in umbilical artery Doppler flow, including absent or reverse end-diastolic flow
- Receiving anticoagulation therapy
- Suspected chromosomal anomalies or multifetal pregnancy
- Active smoking during pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Outpatient Treatment
Duration - 4 weeks
Participants practice left-lateral recumbent positioning for a total of 4 hours daily with intermittent stretching, along with mild to moderate intensity exercise 2-3 times per week and a healthy diet. Activity is recorded via a smart watch.
Daily at-home activity tracking with smart watch; periodic clinical visits as per protocol
Trial Site Locations
Total: 2 locations
1
UCHealth Prenatal Diagnosis and Genetics Clinic - Anschutz Medical Campus
Aurora, Colorado, United States, 80045
Actively Recruiting
2
CU John C. Hobbins Perinatal Center
Denver, Colorado, United States, 80202
Actively Recruiting
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Research Team
H
Hannah E Vincent, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/26375044The effect of bedrest in hospital on fetal outcome in pregnancies complicated by intra-uterine growth retardation.
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