Efficacy of Propranolol to Reduce Cesarean Delivery in Prolonged Labor: A Randomized Controlled Trial.
Jennifer A McCoy, Lauren Walheim, Meaghan G McCabe...
https://pubmed.ncbi.nlm.nih.gov/37290102/Actively Recruiting
Led by Washington University School of Medicine · Updated on 2026-03-13
82
Participants Needed
1
Research Sites
8 weeks
Total Duration
Researchers are investigating whether a specific series of maternal position changes can improve outcomes for patients experiencing prolonged labor. This pilot, randomized control trial focuses on patients with prolonged first stage labor, aiming to assess if a nurse-led circuit of position changes reduces labor duration, improves maternal and newborn health, and increases maternal satisfaction and sense of control during labor. The study emphasizes reducing cesarean delivery rates by exploring effective labor management techniques. Participants will be randomly assigned to either receive a nurse-led circuit of maternal position changes every 2 hours, repeated up to three times, or continue with routine care involving standard position changes like walking and sitting. The circuit includes specific positions such as side-lying releases, open-knee chest, shaking apples, flying cowgirl, and running man, with continuous fetal monitoring throughout. Nurses will be trained and supported to carry out these maneuvers, and adherence and any deviations will be tracked. During the study, data on labor progression, delivery outcomes, and maternal and neonatal health will be collected by blinded reviewers. After delivery, participants will complete a brief survey assessing satisfaction, control over labor, and acceptance of the position changes. The primary measure is the duration of the first stage of labor, with secondary outcomes including mode of delivery, labor lengths, maternal and neonatal morbidity, and maternal satisfaction. Safety will be monitored closely, and the total participation includes labor and delivery through postpartum discharge.
CONDITIONS
Maternal Maneuvers During Prolonged Labor
D
Drew Hensel Maternal Fetal Medicine Fellow, MD
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Washington University School of Medicine
Lead Sponsor
Barnes-Jewish Hospital
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Circuit of maternal position changes | Routine position changes (standard care) |
|---|---|---|
| What it is | A structured circuit of timed maternal position changes (side‑lying, open‑knee chest, shaking apples, ‘flying cowgirl’ and ‘running man’ positions every 2 hours) repeated up to three times or until delivery, arrest diagnosis, or second‑stage onset | Routine or customary maternal position changes during labor without a structured timed circuit |
| Primary use in trial | To reduce the duration of the first stage of labor in cases of prolonged labor | To serve as the usual care comparison for evaluating effects on labor duration and maternal‑neonatal outcomes |
| Evidence status | Effect on first‑stage labor duration is under investigation in this randomized pilot trial; no published results yet | Routine position changes are part of usual labor support; systematic reviews suggest upright or mobile positions may shorten first‑stage labor and reduce cesarean rates |
| Important limitations | Pilot study with small sample (82 participants), no safety or effectiveness data published yet | Existing evidence is based on general upright‑versus‑recumbent positions, not the specific circuit being tested |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - From randomization until delivery
Participants with prolonged first stage labor are randomized to either a specific circuit of nurse-led maternal position changes repeated every 2 hours up to 3 times, or routine labor care with position changes as per clinical discretion.
Continuous monitoring during labor and delivery stay
Duration - Until hospital discharge postpartum
Participants complete a maternal satisfaction survey during postpartum stay assessing their labor experience, sense of control, and acceptability of the position changes if applicable. Outcomes and safety data are collected from delivery until hospital discharge.
1 postpartum visit (in-person) for survey and assessment
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Lead Sponsor
Barnes-Jewish Hospital
Collaborating Sponsor