Actively Recruiting
MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer
Led by Rachel Miller · Updated on 2025-11-13
625
Participants Needed
1
Research Sites
250 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to estimate the recurrence-free survival rates in women with endometrial cancer treated with selective versus sentinel node surgical staging. This study will gather information to help determine the best way to evaluate lymph nodes during surgery for endometrial cancer.
CONDITIONS
Official Title
MCC-24-GYN-11: Comparison of Nodal Sampling in Endometrial Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Surgical candidate for complete hysterectomy and bilateral salpingo-oophorectomy with pelvic and aortic lymphadenectomy
- Histologically or cytologically confirmed carcinoma of the endometrium confined to the uterine corpus
- No clinical evidence of extra-uterine disease on pre-operative evaluation
- Prior systemic chemotherapy allowed if at least five years before enrollment with no evidence of disease
- Life expectancy of at least 6 months
- AST(SGOT)/ALT(SGPT) less than 3 times upper limit of normal
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- GOG Performance Status greater than 2
- Uterine sarcoma
- Clinical evidence of disease beyond the uterus including suspicious nodes on imaging or exam
- Previous vaginal, pelvic or abdominal irradiation
- Chemotherapy or immunotherapy directed at the present disease
- Previous pelvic lymphadenectomy or retroperitoneal surgery
- Prior or concurrent malignancy interfering with study assessment
- Known allergy to iodine or indocyanine green tracer
- Uncontrolled intercurrent illness
- Psychiatric illness or social situations limiting study compliance
- Pregnant or lactating women or positive pregnancy test for women of child-bearing potential
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40506
Actively Recruiting
Research Team
R
Rachel Miller
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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