Actively Recruiting

Age: 55Years - 80Years
All Genders
Healthy Volunteers
NCT06102486

MCI Speech in Noise

Led by Dartmouth-Hitchcock Medical Center · Updated on 2026-01-13

70

Participants Needed

1

Research Sites

102 weeks

Total Duration

On this page

Sponsors

D

Dartmouth-Hitchcock Medical Center

Lead Sponsor

D

Dartmouth College

Collaborating Sponsor

AI-Summary

What this Trial Is About

The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.

CONDITIONS

Official Title

MCI Speech in Noise

Who Can Participate

Age: 55Years - 80Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults diagnosed with or suspected to have MCI (for MCI group) or are cognitively normal (for Control group)
  • Absence of other risk factors that might affect Central Auditory Processing performance such as active ear infections, congenital developmental delay, or severe hearing loss
  • Age between 55 and 80 years
  • Normal hearing sensitivity with less than 40 dB HL Pure Tone Average thresholds bilaterally (average of 500, 1000, 2000 Hz)
  • Normal middle ear function defined by tympanometry between 0.3 and 2.0 ml
  • Native English speaker
Not Eligible

You will not qualify if you...

  • Active ear infections or abnormal middle ear pathology
  • Other health conditions that prevent completion of the Central Auditory Processing test battery
  • Mild to profound peripheral hearing loss greater than 40 dB HL Pure Tone Average bilaterally
  • Adults unable to provide consent
  • Individuals who are not adults (infants, children, teenagers)
  • Prisoners
  • History of central nervous system disorders impacting cognition such as Alzheimer's, Parkinson's, multiple sclerosis, neurosyphilis, intracranial tumors, significant head trauma with loss of consciousness of 30 minutes or more, or cerebrovascular disease
  • Severe mental illness such as schizophrenia or bipolar disorder
  • Current uncontrolled medical conditions that could affect cognition like hypertension
  • History of substance use disorder (except nicotine or caffeine)
  • Non-correctable severe hearing or vision loss
  • Use of cognition enhancing drugs
  • Frequent, severe headaches (occasional headaches or migraines allowed)

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Space Medicine Lab at Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States, 03756

Actively Recruiting

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Research Team

S

Samantha Leigh, BS

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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