Actively Recruiting
Measles and BCG Vaccines for Mother and Child
Led by Bandim Health Project · Updated on 2024-01-19
2400
Participants Needed
1
Research Sites
345 weeks
Total Duration
On this page
Sponsors
B
Bandim Health Project
Lead Sponsor
T
The University of Western Australia
Collaborating Sponsor
AI-Summary
What this Trial Is About
In Africa, the mortality from infectious diseases remains high. The investigators have discovered that live vaccines such as the BCG vaccine against tuberculosis and the measles vaccine can strengthen resistance to other infections: they have beneficial "non-specific effects". The investigators have now seen signs that these non-specific effects for children are stronger if their mother has been given the same vaccines. In Africa, BCG vaccine is recommended at birth and measles vaccine at 9 months of age. They are not used beyond childhood. The investigators will randomize 2400 women to BCG vaccine, measles vaccine, or placebo. The investigators will further randomize their children to an extra early measles vaccine or placebo. The investigators will assess which of the resulting six vaccination schedules are best for women's and children's protection against measles, for the child's immune system, and for general health. The project will be the first in the world to investigate the importance of vaccinating women with live vaccines.
CONDITIONS
Official Title
Measles and BCG Vaccines for Mother and Child
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female women in the fertile age
- Non-pregnant
- HIV-negative
- Living in the BHP HDSS study area
- Delivered a child that has reached 12 months of age
- Currently not using contraceptives.
You will not qualify if you...
- Positive pregnancy test
- Positive HIV test
- Tuberculosis (previous or current)
- Immunodeficiency
- Cancer within the last 2 years
- Mid-upper-arm-circumference<200
- Acute ongoing infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bandim Health Project
Bissau, Bissau Codex, Guinea-Bissau, 1004
Actively Recruiting
Research Team
I
Isaquel da Silva, MD
CONTACT
C
Christine Benn, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
PREVENTION
Number of Arms
3
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