Actively Recruiting
Measurement of Head and Neck Tumor Hypoxia With PET-MRI
Led by Turku University Hospital · Updated on 2022-02-18
30
Participants Needed
1
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is designed to evaluate the performance of advanced magnetic resonance (MR) imaging in the assessment of tumor hypoxia using \[18F\]EF5 positron emission tomography (PET) as a reference in head and neck cancer patients. Low oxygen level or hypoxia contributes to radiotherapy resistance. Therefore, a clinically applicable method to detect tumor hypoxia is of great importance.
CONDITIONS
Official Title
Measurement of Head and Neck Tumor Hypoxia With PET-MRI
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years old
- Male or female
- Speak Finnish or Swedish
- Karnofsky performance score 70 or better, or WHO performance status 2 or better
- Able to understand the study purpose
- Diagnosed with squamous cell carcinoma of the head and neck (oral cavity, pharynx, or larynx)
- Primary tumor diameter of at least 20 mm
- Patients with nodal neck metastases of head and neck cancer
- Signed informed consent approved by the Ethical Committee
- If female, not pregnant or breastfeeding at the time of the study
You will not qualify if you...
- Contraindications to MR imaging (such as metallic implants, pacemakers, MR-incompatible heart valves, contrast allergy, or claustrophobia)
- History of serious blood, heart, liver, or kidney disease (final decision by investigators)
- Previous chemotherapy, biological therapy, immunotherapy, radiotherapy, or major surgery for head and neck cancer
- Uncontrolled serious infection
- Advanced disease making curative cancer treatment not possible
AI-Screening
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Trial Site Locations
Total: 1 location
1
Turku University Hospital
Turku, G102881, Finland, 20521
Actively Recruiting
Research Team
J
Jussi Hirvonen, MD, PhD
CONTACT
A
Antti Silvoniemi, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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