Actively Recruiting
Measuring Changes In Choroidal Thickness Induced By Prototype Soft Contact Lenses Worn For 1 Hour
Led by Myoptechs, Inc · Updated on 2025-09-04
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Myoptechs, Inc
Lead Sponsor
U
University of Waterloo School of Optometry and Vision Science
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how three different prototype soft contact lenses affect the thickness of the choroid, a layer in the eye, in people with myopia (nearsightedness). This study aims to observe short-term changes in choroidal thickness after wearing each lens for a short period. The trial is designed as a randomized, double-masked study to compare the effects of these lenses. Participants will wear each of the three prototype soft contact lenses—Lens A, Lens B, and Lens C—for one hour each. The study uses a randomized order for lens wear, and each lens is evaluated separately. There is no placebo group; all participants will experience the three experimental lenses during the study. During the study, participants will undergo eye measurements to assess the change in choroidal thickness from baseline after one hour of wearing each lens. Researchers will monitor adherence to instructions such as avoiding caffeine, alcohol, smoking, or recreational cannabis before visits. The primary outcome is the change in choroidal thickness after lens wear. The study will continue until December 2025 and includes regular measurement visits following a set schedule.
CONDITIONS
Brief Title
Measuring Changes In Choroidal Thickness Induced By Prototype Soft Contact Lenses Worn For 1 Hour
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Are 18-25 years of age (inclusive) and have full legal capacity to volunteer
- Habitually wear soft contact lenses or have previous experience wearing them
- Are myopic with both eyes having a vertex corrected spherical equivalent non-cycloplegic refraction between -0.50 DS and -4.50 DS
- Have visual acuity of at least LogMAR +0.10 with spherical equivalent refraction in each eye
- Willing and able to maintain appointment schedule and follow instructions including no caffeine, alcohol, or stimulants 12 hours before visits and no smoking or cannabis 24 hours before visits
- Have not used any myopia control treatment in the past 2 years
- Typically sleep at least 7 hours per night
You will not qualify if you...
- Participating in any other clinical or research study
- Have astigmatism greater than 1.00 DC in either eye
- Have amblyopia or any other binocular vision disorder such as accommodative insufficiency
- Have any active ocular disease or infection
- Have systemic conditions affecting study outcomes such as diabetes, hyperthyroidism, or active allergies
- Use systemic or topical medications that may affect study outcomes such as antihistamines or atropine eye drops
- Known sensitivity to sodium fluorescein diagnostic pharmaceutical
- Are pregnant, lactating, or planning pregnancy at enrollment
- Have had strabismus surgery, refractive error surgery, or intraocular surgery
- Are employees of the Centre for Ocular Research & Education involved in this study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Each lens worn for 1 hour
Participants wear prototype soft contact lenses to measure changes in choroidal thickness.
Multiple visits to wear Lens A, Lens B, and Lens C
Trial Site Locations
Total: 1 location
1
Centre for Ocular Research and Education at the School of Optometry and Vision Science at Waterloo University
Waterloo, Ontario, Canada, N2L 3G1
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
3
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