Comparing Knee Biomechanics After Mechanical or Kinematic Total Knee Replacement One-Year Follow-Up Study on Clinical and Imaging Outcomes

What this Trial Is About

Researchers are comparing two different techniques for aligning total knee prostheses TKA in adults with knee osteoarthritis. The traditional mechanical alignment MA method uses fixed bone cuts based on mechanical axes and does not restore the knees original anatomy, which can lead to residual symptoms and dissatisfaction. The newer kinematic alignment KA technique aims to personalize the prosthesis placement according to each patients unique pre-arthritic knee anatomy, although its biomechanical impact is still not well understood. This study seeks to compare knee biomechanics between mechanical and kinematic TKA methods. The trial involves two groups of patients who have received either a mechanically aligned or a kinematically aligned total knee prosthesis. Patients in the KA group are consecutively selected during post-operative follow-up consultations at least one year after surgery, while the MA group is matched by sex, age, and BMI for comparison. Both interventions are evaluated as devices during routine clinical care, with no randomization or blinding involved. Participants are assessed one year after surgery through various biomechanical parameters including spatiotemporal, kinematic, joint moment, force, and lever arm measurements, as well as the symmetry between the operated and healthy knee. Clinical outcomes such as function, pain, joint perception, satisfaction, range of motion, and complications are also measured. Imaging studies using EOS 3D and radiography evaluate implant alignment, fixation, and bone structure. The study also includes patient-reported outcomes to provide a comprehensive view of recovery and prosthetic performance.

Mechanically or Kinematically Aligned Total Knee Prosthesis