Actively Recruiting
Mechanism of Non-invasive Magnetic Stimulation
Led by National Institute on Drug Abuse (NIDA) · Updated on 2026-05-14
70
Participants Needed
1
Research Sites
432 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: Transcranial magnetic stimulation (TMS) is form of non-invasive brain stimulation. It is approved to treat depression. TMS may help decrease drug craving. It is important to understand how TMS affects the brain. Such a better understanding would help to design ways to treat drug addiction. Objectives: To learn how TMS affects the brain when it stimulates an area in the front of the brain. Also, to see how the stimulation affects the area stimulated and other connected areas. Eligibility: Healthy, right-handed adults ages 18-60 who are non-drug users. Design: Participants will be screened under protocol 06-DA-N415. Participants will have at least 3 visits. The first visit will last about 3 hours. All other visits will last up to 6 hours. Participants cannot use drugs or alcohol at least 24 hours before a visit. They cannot have more than half a cup of a caffeinated drink at least 12 hours before a visit. Each visit will include a brief medical history update, urine test for drugs and pregnancy (if female), a breath test for alcohol and smoking, and questionnaires. Participants will have a TMS orientation visit. A wire coil will be placed on the head. An electrical current will pass through the coil to create a magnetic pulse that stimulates the brain. The other visits will include 2 sessions of TMS-MRI. Participants will lie on a table that slides into a cylinder. The TMS coil and the MRI coil will be placed over the head. Pictures will be taken of the brain with and without stimulation. Participants will complete a questionnaire about how they feel before and after each TMS session and in a follow-up call 1-3 days after their last session.
CONDITIONS
Official Title
Mechanism of Non-invasive Magnetic Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be between 18 and 60 years old
- Be in good health with no major illnesses
- Be right-handed
- Be a healthy adult non-drug user
- Able to undergo MRI and TMS procedures safely
You will not qualify if you...
- History of stroke, brain lesions, neurosurgery, seizures, fainting of unknown cause, or serious head injury
- Family history of epilepsy with hereditary basis
- Have cardiac pacemakers, neural stimulators, defibrillators, implanted pumps, intracardiac lines, intracranial implants, or other metal objects that prevent MRI or TMS
- Any contraindications to MRI or TMS, including claustrophobia
- Noise-induced hearing loss or tinnitus
- Use of investigational drugs or medications affecting brain activity in past 6 months
- Lifetime or current history of major psychiatric disorders such as depression, schizophrenia, bipolar disorder, mania, or hypomania
- Current or heavy past nicotine use or smoking
- Current substance use disorder or positive drug test inconsistent with history
- Past substance use disorder
- Pregnancy or not using acceptable contraception if of reproductive potential
- Participation in rTMS session less than two weeks ago
- History of learning disability, ADHD, or cognitive impairment
- Non-English speaking
AI-Screening
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Trial Site Locations
Total: 1 location
1
National Institute on Drug Abuse
Baltimore, Maryland, United States, 21224
Actively Recruiting
Research Team
N
NIDA IRP Screening Team
CONTACT
Y
Yihong Yang, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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