Study of Red Yeast Rice Effects on Gut Indole Metabolism and Chronic Inflammation in Women with Polycystic Ovary Syndrome

What this Trial Is About

Researchers are studying the effects of red yeast rice on symptoms in women with polycystic ovary syndrome PCOS. The study aims to understand how red yeast rice may improve PCOS symptoms and to explore the relationship between gut bacteria metabolism, specifically the indole pathway, and clinical signs of PCOS. The study is an early phase 1 clinical trial led by Sichuan Provincial Peoples Hospital. Participants will take 6 grams of red yeast rice daily for 6 months. The red yeast rice contains various components like monacolins and pigments thought to affect metabolic diseases. The study will monitor changes before treatment, at 3 months, and at 6 months, including clinical symptoms and biological samples from feces and blood to analyze gut microbiota metabolites. During the study, participants will have regular assessments measuring inflammation markers, sex hormones, ovarian follicle characteristics, and hydroxyindole levels. Body mass index and waist-to-hip ratio will also be tracked. These evaluations occur at baseline, 3 months, and 6 months post-intervention to monitor progress and safety throughout the study period, which lasts 6 months in total.

Mechanism of Red Yeast Rice Regulating Intestinal Indole Metabolism Pathway to Improve Chronic Inflammation in Polycystic Ovary Syndrome