Actively Recruiting
Mechanism of Red Yeast Rice Regulating Intestinal Indole Metabolism Pathway to Improve Chronic Inflammation in Polycystic Ovary Syndrome
Led by Sichuan Provincial People's Hospital · Updated on 2025-08-06
90
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
Sponsors
S
Sichuan Provincial People's Hospital
Lead Sponsor
L
Lishui Hospital of Traditional Chinese Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this study is to elucidate the effects of red yeast rice on the improvement of symptoms in patients with polycystic ovary syndrome（PCOS）, and to analyze the dose-response relationship between intestinal microbiota and its metabolite, hydroxyindole, and clinical indicators of PCOS. The main questions it aims to answer are: How effective is red yeast rice in treating PCOS? Does the indole metabolic pathway of gut microbiota play a crucial role in the improvement of PCOS symptoms by red yeast rice? Participants will take 6 grams of red yeast rice daily for 6 months, and records will be kept of their PCOS clinical symptoms and indicators before the intervention, at the 3rd month post-intervention, and at the 6th month post-intervention. Additionally, biological samples from feces and serum will be collected at these time points.
CONDITIONS
Official Title
Mechanism of Red Yeast Rice Regulating Intestinal Indole Metabolism Pathway to Improve Chronic Inflammation in Polycystic Ovary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18-40 years old
- Meeting the Rotterdam criteria with at least two of the following: anovulation or oligo-ovulation, clinical evidence of hyperandrogenism or hyperandrogenemia, ultrasound showing polycystic ovarian morphology
- Fully informed about study procedures and risks and voluntarily agreeing to participate
You will not qualify if you...
- Pregnant women confirmed by urine or serum hCG test
- Patients with infectious diseases or severe dysfunction of multiple systemic organs
- Patients who have taken antibiotics or drugs affecting intestinal flora such as probiotics or prebiotics within 3 months before enrollment
AI-Screening
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Trial Site Locations
Total: 1 location
1
Lishui Hospital of Traditional Chinese Medicine
Lishui, Zhejiang, China, 323000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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