Actively Recruiting
Mechanism of TIPS to Improve Sarcopenia
Led by Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Updated on 2026-02-11
132
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
U
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor
T
The First Affiliated Hospital of Zhengzhou University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Sarcopenia is particularly common in patients with chronic liver disease, especially in patients with decompensated cirrhosis, where the prevalence can be more than 50%. Sarcopenia is an important risk factor for a significant increase in mortality in cirrhotic patients, and is closely associated with a high incidence of complications such as hepatic encephalopathy, ascites, and infections . Recent studies have found that TIPS not only significantly improves clinical symptoms caused by portal hypertension, but may also have a positive effect on skeletal muscle mass and function in patients. Although the effect of TIPS in improving sarcopenia has been preliminarily confirmed, its mechanism is not yet fully understood. Therefore, there is an urgent need to explore the mechanism of action of TIPS to improve sarcopenia and provide guidance for clinical treatment options.
CONDITIONS
Official Title
Mechanism of TIPS to Improve Sarcopenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with liver cirrhosis and needing TIPS surgical treatment
- Aged between 18-80 years old
- Able to understand and sign the informed consent form and willing to cooperate in completing the examinations and follow-up visits
You will not qualify if you...
- Serious cardiovascular and cerebrovascular diseases such as acute myocardial infarction or severe heart failure
- Having malignant tumors in the active stage
- History of major surgeries or traumas within the last 3 months
- Presence of mental illness or cognitive disorders that prevent cooperation
- Receiving special treatments that may affect study results, such as immune-suppressing agents or hormones
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Taiwan, 430022
Actively Recruiting
Research Team
J
Jiacheng Liu Dr.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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