Actively Recruiting
Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
Led by University of Oregon · Updated on 2025-11-17
150
Participants Needed
1
Research Sites
196 weeks
Total Duration
On this page
Sponsors
U
University of Oregon
Lead Sponsor
O
Oregon Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.
CONDITIONS
Official Title
Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 14 to 18 years of age
- Currently in high school
- Have short and late sleep (weekday sleep duration 64 7 hours and bedtime 65 10:30 pm) or long and early sleep (weekday sleep duration > 7 hours and bedtime 64 10:30 pm), based on the Munich Chronotype Questionnaire
- Experienced two or more lifetime stressful events on the Stress and Adversity Inventory Screener
- Depressive symptom severity t-score of 45 or higher on the PROMIS Depression scale
- Fluent in English
You will not qualify if you...
- Current moderate to severe alcohol or substance use disorder with four or more symptoms
- Diagnosed with narcolepsy or idiopathic hypersomnia
- Lifetime diagnosis of bipolar disorder or schizophrenia spectrum disorder
- Serious medical conditions such as major neurological disorder, heart failure, or history of head injury with unconsciousness over 5 minutes
- Conditions preventing magnetic resonance imaging (MRI), like metal in the body
- Eye disease, epilepsy, or use of photosensitizing medications contraindicated with bright light therapy
- Use of melatonin if unwilling to stop during the study
- Urgent suicide risk requiring immediate action
- Recent travel across two or more time zones within one month before study visits
- Starting or stopping prescribed medications within 2 months of the study
- Changes in prescribed medication dose within five times the drug's half-life before study start
- Anticipated medication changes during the study
- Current symptoms of airborne infectious illness before lab visits
- Positive breathalyzer with blood alcohol level over 0.02 at study visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Oregon
Eugene, Oregon, United States, 97403
Actively Recruiting
Research Team
A
Amanda Johnson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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