Actively Recruiting

Phase 1
Age: 18Years +
All Genders
NCT05323487

Mechanisms of Diuretic Resistance in Heart Failure, Aim 1

Led by Yale University · Updated on 2025-01-13

75

Participants Needed

1

Research Sites

230 weeks

Total Duration

On this page

Sponsors

Y

Yale University

Lead Sponsor

N

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborating Sponsor

AI-Summary

What this Trial Is About

This study will employ a randomized order, double-blind, repeated measures dose ranging design. This design was chosen in order to generate multiple within-subject serial loop diuretic dose response exposures. The overall study schema will include 75 heart failure (HF) patients.

CONDITIONS

Official Title

Mechanisms of Diuretic Resistance in Heart Failure, Aim 1

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Clinical diagnosis of heart failure
  • No planned changes in heart failure medications or devices during the study
  • No non-elective hospitalizations in the past 3 months
  • Stable volume status by symptoms, exam, and dry weight
  • Age greater than 18 years
Not Eligible

You will not qualify if you...

  • Glomerular filtration rate less than 20 ml/min/1.73m2 or use of renal replacement therapy
  • Use of non-loop diuretics in the last 14 days except low dose aldosterone antagonists (≤50 mg)
  • History of flash pulmonary edema needing hospital treatment with breathing support or "brittle" volume sensitive heart failure types like infiltrative cardiomyopathy
  • Hemoglobin less than 8 g/dL
  • Pregnant or breastfeeding
  • Unable to give informed consent or comply with the study
  • Chronic urinary retention affecting urine collection

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Yale University

New Haven, Connecticut, United States, 06510

Actively Recruiting

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Research Team

V

Veena Rao

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

SEQUENTIAL

Primary Purpose

OTHER

Number of Arms

4

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