Understanding Muscle Fatigue and Exercise Benefits in Adults with Pre-Diabetes and Type 2 Diabetes An 8-Week Study of Resistance Training with Blood Flow Restriction

What this Trial Is About

Researchers are investigating the causes of increased muscle fatigue during exercise in people with pre-diabetes Pre-D and type 2 diabetes T2D. The study aims to understand whether blood vessel problems at various levels contribute to this fatigue. This trial evaluates a new exercise training method that uses blood flow restriction to better understand how vascular function affects exercise performance in these groups. Participants with Pre-D and T2D will engage in an 8-week exercise program involving dynamic resistance training of the leg muscles. One leg will exercise normally without blood flow restriction, while the other leg will exercise with blood flow restricted by an inflatable cuff. This approach tests how restricting blood flow during exercise influences muscle fatigue and vascular health. During the study, participants will attend three exercise sessions per week for eight weeks. Researchers will measure muscle fatigue, strength, blood flow, oxygen levels in muscles, and blood vessel function before and after the training. Various assessments include muscle biopsies, Doppler ultrasound, and near infrared spectroscopy NIRS. The study monitors changes in muscle metabolism, capillary density, and vascular responses to evaluate effects of the training program.

Mechanisms of Fatigability With Diabetes