Actively Recruiting
Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism
Led by Boston Children's Hospital · Updated on 2025-04-18
111
Participants Needed
1
Research Sites
354 weeks
Total Duration
On this page
Sponsors
B
Boston Children's Hospital
Lead Sponsor
N
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This protocol is primarily looking to see if the IL-4Ra R576 polymorphism is associated with increased clinical, immunological and microbial markers of disease activity in patients with Atopic dermatitis.
CONDITIONS
Official Title
Mechanisms of Increased Disease Severity in AD Patients With the IL-4Ra R576 Polymorphism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female participants aged 6 to 65 years
- Must meet standard diagnostic criteria for atopic dermatitis
You will not qualify if you...
- Currently enrolled in another clinical trial
- Hypersensitivity to agents used in skin decolonization
- Use of systemic immunosuppressive or immunomodulating drugs within 4 weeks
- Phototherapy for atopic dermatitis within 4 weeks
- Treatment with biologic drugs within 16 weeks
- Use of topical steroids, topical calcineurin inhibitors, or crisaborale within 7 days
- Bleach baths within 7 days before the visit
- Use of oral or topical antibiotics within 21 days before the study
- Asthma requiring more than 500 mcg per day of inhaled corticosteroids
- History of HIV, hepatitis B, hepatitis C, tuberculosis, or malignancy
- Skin diseases interfering with assessments, such as psoriasis or cutaneous T cell lymphoma
- Severe medical illnesses like cardiovascular, kidney, or autoimmune diseases
- Fever at the time of visits
- Suspected immune deficiency or family history of primary immunodeficiency
AI-Screening
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Trial Site Locations
Total: 1 location
1
Boston Children's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
R
Rachel Dabek, MD. MPH.
CONTACT
H
Hannah Foster
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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