Actively Recruiting
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
Led by University of Edinburgh · Updated on 2025-06-11
300
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
B
British Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions this study aims to answer are: 1. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) more likely than those without damage to the heart to have blocked heart arteries (obstructive coronary artery disease) 2. Are patients with a fast, irregular heartbeat (rapid AF) and damage to the heart (myocardial injury) with further evidence that their heart hasn't been getting enough oxygen (myocardial ischemia) more likely to have imaging evidence of myocardial infarction than those without myocardial ischemia To do this, we will measure troponin in patients with rapid AF and then carry out further investigations of the heart (electrocardiogram, echocardiogram, CT scan and cardiac MRI)
CONDITIONS
Official Title
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years and over
- Primary presentation with symptoms related to atrial fibrillation
- Atrial fibrillation with a ventricular rate >100 bpm on a 12-lead electrocardiogram
- Able to provide informed consent
You will not qualify if you...
- Previous myocardial infarction
- Previous coronary revascularisation procedure
- Patients in renal failure (eGFR <30ml/min/1.73m2) or major allergy to contrast media
- Pregnancy or breast feeding
- Deemed unsuitable for participation in the study by the attending clinician
- Previous enrolment in the trial
AI-Screening
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Trial Site Locations
Total: 1 location
1
Royal Infirmary of Edinburgh
Edinburgh, East of England, United Kingdom
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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