Actively Recruiting
Mechanisms of Open and Hidden Placebo in Stroke Recovery
Led by Spaulding Rehabilitation Hospital · Updated on 2025-09-17
56
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
CONDITIONS
Official Title
Mechanisms of Open and Hidden Placebo in Stroke Recovery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with hemiparesis due to chronic stroke
- Stroke duration of 6 months or more
- Fugl-Meyer scale upper extremity motor assessment score greater than 11 and less than or equal to 56
- Pre-stroke disability score less than 3 on the Modified Rankin Scale
- Age 18 years or older
You will not qualify if you...
- Stroke in the anterior cerebral artery area with prefrontal brain damage and reduced EEG power in the prefrontal cortex
- Unable to understand instructions
- Contraindications to transcranial magnetic stimulation such as electronic hardware near the stimulation coil (e.g., cochlear implant, internal pulse generator, medical pump)
- Unstable medical conditions
- Hamilton Depression Rating Scale score of 24 or higher
- Joint or affected limb pain likely to affect assessments
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Spaulding Hospital Cambridge
Cambridge, Massachusetts, United States, 02138
Actively Recruiting
Research Team
F
Felipe Fregni, MD, PhD, MPH
CONTACT
E
Elly Pichardo, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
4
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