Actively Recruiting
Mechanisms Preventing Pharyngeal Reflux
Led by Medical College of Wisconsin · Updated on 2026-02-10
300
Participants Needed
1
Research Sites
675 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall goal is to define and characterize the manometric characteristics of UES incompetence associated with objectively documented pharyngeal reflux. The investigators will use endoscopic reflux detection as gold standard.
CONDITIONS
Official Title
Mechanisms Preventing Pharyngeal Reflux
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 85 years
- GERD patients with regurgitation and supra-esophageal symptoms
- GERD patients without supra-esophageal symptoms and regurgitation
- Asthma patients with intermittent, mild persistent, moderate persistent, or severe persistent asthma, without acute exacerbation
- Diagnosis based on American Gastroenterological Association and Montreal definitions of GERD
- SERD patients on long-term acid suppressive therapy with persistent regurgitation and supra-esophageal symptoms, screened by Reflux Symptom Index > 13
- Barrett's esophagus patients diagnosed histologically by previous endoscopic biopsy
You will not qualify if you...
- Age under 18 or over 85 years
- Active alcohol or drug abuse
- History of ear, nose, throat, or pulmonary diseases suspected to be induced by GERD
- History of head and neck cancer or chemo-radiation therapy to the head and neck
- Unable to give consent
- Pregnant women
- Allergy to lidocaine used in nasal anesthesia
- Allergy to green food dye
- Asthma patients currently experiencing an acute asthma exacerbation with breathlessness, wheezing, or chest tightness
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53086
Actively Recruiting
Research Team
R
Reza Shaker, MD
CONTACT
M
Mark Kern
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
5
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