Actively Recruiting
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
Led by University of Oregon · Updated on 2026-02-27
90
Participants Needed
1
Research Sites
181 weeks
Total Duration
On this page
Sponsors
U
University of Oregon
Lead Sponsor
U
University of Pittsburgh
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.
CONDITIONS
Official Title
Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 24 years
- Past-month high-risk drinking defined as 4 drinks/day or 8/week for women, 5 drinks/day or 15/week for men
- Short and late sleep (weekday sleep 7.5 hours and bedtime at or after midnight) or long and early sleep (weekday sleep over 7.5 hours and bedtime before midnight)
- At least moderate lifetime exposure to stressors (2 or more events on the 20-item Adult Stress and Adversity Inventory-Screener)
- Not currently in high school
- Fluent in English
You will not qualify if you...
- Severe alcohol or substance use disorder (6 or more criteria in Diagnostic and Statistical Manual-5)
- Acute alcohol intoxication on laboratory visit days (blood alcohol concentration of 0.02 or higher)
- Current diagnosis of narcolepsy or idiopathic hypersomnia
- Lifetime diagnosis of bipolar or schizophrenia spectrum disorder
- Serious medical conditions such as neurological disorders, heart failure, or head injury with unconsciousness over 5 minutes
- Conditions preventing MRI (e.g., ferrous metal in body)
- Eye disease, epilepsy, or use of photosensitizing medications contraindicated with bright light therapy
- Use of melatonin without willingness to stop during the study
- Recent urgent suicide risk requiring immediate action
- Recent travel across two or more time zones within one month prior to visits
- Starting or stopping prescribed medication within 2 months before the study
- Medication dose changes within five times the drug's half-life before study start
- Anticipated medication changes during the study
- Current symptoms of airborne infectious illness prior to lab visits
- Positive breathalyzer screen (blood alcohol level > 0.02) on visit days, requiring rescheduling
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oregon Sleep Lab
Eugene, Oregon, United States, 97403
Actively Recruiting
Research Team
A
Amanda Johnson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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