Actively Recruiting
Mechanisms of Rumination Change in Adolescent Depression
Led by Ohio State University · Updated on 2025-08-11
183
Participants Needed
3
Research Sites
513 weeks
Total Duration
On this page
Sponsors
O
Ohio State University
Lead Sponsor
U
University of Exeter
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.
CONDITIONS
Official Title
Mechanisms of Rumination Change in Adolescent Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previous diagnosis of Major Depressive Disorder (full or partial remission for at least two weeks) confirmed by KSADSPL
- Rumination Responsiveness Scale score above age and sex specific mean (T > 50)
- Age 14 to 17 years at enrollment
- Postpubertal as assessed by Petersen Pubertal Developmental Scale
- Youth assent and parent consent obtained
- Intellectual Quotient (IQ) above 75 as determined by WASI
You will not qualify if you...
- Suicidality with plan or intent currently or within past 3 months
- Lifetime history of conduct disorder, autism, any psychotic disorder, or bipolar disorder
- Eating disorder or alcohol/substance abuse within past 6 months
- Current treatment or treatment in past 2 years with RF-CBT, CBT, or similar structured therapies
- Presence of metal braces, retainers, tattoos with metal, or clothing with metal fibers
- Claustrophobia
- Current pregnancy or inadequate birth control in sexually active females
- Use of psychotropic medications other than stable antidepressants
- Antidepressant dose changes within past 4 weeks or medication changes within past 6 weeks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
Actively Recruiting
2
The Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
3
University of Utah
Salt Lake City, Utah, United States, 84108
Actively Recruiting
Research Team
S
Scott A Langenecker, Ph.D.
CONTACT
C
Caty Escobar, M.S.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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