Actively Recruiting
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
Led by First Affiliated Hospital of Zhejiang University · Updated on 2023-01-13
60
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.
CONDITIONS
Official Title
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current episode meets DSM-5 criteria for major depression without psychotic symptoms
- 24-item Hamilton Depression Scale (HAMD-24) score of 20 or higher
- Age between 18 and 45 years
- Right-handed
- Han Chinese ethnicity
- Signed informed consent and willing to participate and be evaluated
You will not qualify if you...
- Other mental disorders such as schizophrenia, mental retardation, or substance dependence
- Presence of metal objects in the body or contraindications to MRI
- Severe or unstable physical illnesses
- Women who are pregnant, breastfeeding, or have a positive urine pregnancy test during screening
- Any other condition deemed inappropriate for participation by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
Research Team
M
Manli Huang, M.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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