Actively Recruiting
Mechanisms Underlying the Efficacy of Prolonged Exposure
Led by VA Boston Healthcare System · Updated on 2025-04-08
50
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
V
VA Boston Healthcare System
Lead Sponsor
N
National Center for PTSD
Collaborating Sponsor
AI-Summary
What this Trial Is About
The primary objective of this research is to collect pilot data that demonstrates that proposed neural, psychophysiological and subjective markers measured before, during, and after treatment change over the course of Prolonged Exposure therapy (PE) for posttraumatic stress disorder (PTSD). The aims of the study are to: (1) examine theoretically informed mechanisms as pre-treatment predictors of PE treatment efficacy, (2) characterize how neural, psychophysiological, and subjective markers measured before, during, and after treatment change over the course of PE, and (3) examine proposed mechanisms of change as measures of PE treatment efficacy. This is a longitudinal study of predictors of exposure therapy efficacy that will be conducted within the context of a standard 10 session PE treatment trial, with independent multimodal assessment batteries administered at pre-treatment, mid-treatment, post-treatment, and at 1-month follow-up. This data will be used to support a future NIMH and/or VA grant submission.
CONDITIONS
Official Title
Mechanisms Underlying the Efficacy of Prolonged Exposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of PTSD according to DSM-5 criteria confirmed by CAPS-5
- Interest in starting Prolonged Exposure therapy
- Veteran status
You will not qualify if you...
- Current or past diagnosis of schizophrenia or other psychotic disorders
- Untreated Bipolar Disorder or manic/mixed episode in last 6 months
- Severe traumatic brain injury
- Major neurological problems
- Current substance use disorder
- Active risk to self or others
- Current participation in cognitive-behavioral therapy
- Previous receipt of more than 2 Prolonged Exposure therapy sessions
- No memory of traumatic event
- Unstable psychotropic medication use within 2 months prior to enrollment
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
VA Boston Healthcare System
Boston, Massachusetts, United States, 02116
Actively Recruiting
Research Team
S
Suzanne Pineles, PhD
CONTACT
V
Vladimir Ivkovic, Phd
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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