Actively Recruiting
Mechanisms Underlying Efficacy of Prolonged Exposure
Led by Massachusetts General Hospital · Updated on 2025-11-13
50
Participants Needed
1
Research Sites
243 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this research is to collect pilot data that demonstrates that proposed neural, psychophysiological and subjective markers measured before, during, and after treatment change over the course of Prolonged Exposure therapy (PE) for posttraumatic stress disorder (PTSD). The aims of the study are to: (1) examine theoretically informed mechanisms as pretreatment predictors of PE treatment efficacy, (2) characterize how neural, psychophysiological, and subjective markers measured before, during, and after treatment change over the course of PE, and (3) examine proposed mechanisms of change as measures of PE treatment efficacy. This is a longitudinal study of predictors of exposure therapy efficacy that will be conducted within the context of a standard 10 session PE treatment trial, with independent multimodal assessment batteries administered at pre-treatment, mid-treatment, post-treatment, and at 1-month follow-up. This data will be used to support a future NIMH and/or VA grant submission.
CONDITIONS
Official Title
Mechanisms Underlying Efficacy of Prolonged Exposure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 or older
- Meeting diagnostic criteria for PTSD as defined by DSM-5 assessed by the Diagnostic Interview for Anxiety, Mood, and Obsessive-compulsive and related Psychiatric Disorders (DIAMOND)
- Interest in starting Prolonged Exposure therapy
You will not qualify if you...
- Current or past history of schizophrenic or other psychotic disorders
- Untreated Bipolar Disorder or a history of a manic/mixed episode within the last 6 months
- Severe traumatic brain injury
- Major neurological problems
- Current substance use disorder of moderate or greater severity assessed by the DIAMOND
- Active risk to self or others
- Current participation in therapy other than present-centered supportive therapy
- Previously received more than 2 sessions of Prolonged Exposure therapy
- Having no memory of their traumatic event
- For participants on psychotropic medication, medication use must have been stable for 2 months prior to enrollment and remain stable throughout participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
MGH
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
A
Amanda W Baker, Ph.D.
CONTACT
V
Vladimir Ivkovic, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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