Actively Recruiting
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
Led by Aalborg University · Updated on 2025-12-04
30
Participants Needed
1
Research Sites
164 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, two areas will be selected on each forearm of the subjects. The four areas will be treated with the same vehicle cream for 20 minutes, in order to test the placebo effect. At the end of the cream application, two areas will be randomly treated with histamine while cowhage will be applied on the other two areas. During the 10 minutes of the application of the pruritogens, itch and pain will be continuously monitored using a Visual Analog Scale.
CONDITIONS
Official Title
Mechanisms Underlying the Placebo Effect in Both Histaminergic and Non-histaminergic Itch
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy men and women
- Aged 18 to 60 years
- Speak and understand English
You will not qualify if you...
- Pregnancy or lactation
- Drug addiction including use of cannabis, opioids, or other drugs
- History of neurological, immunological, musculoskeletal, cardiac, or psychiatric disorders that may affect results (e.g., neuropathy, muscular pain in upper limbs, anxiety, depression, schizophrenia)
- Moles, wounds, scars, or tattoos in the treatment or testing areas
- Current use of medications that may affect the study such as antihistamines and pain killers
- Skin diseases
- Consumption of alcohol or painkillers within 24 hours before and during study days
- Acute or chronic pain and itch
- Participation in other trials within 1 week before study entry (4 weeks for pharmaceutical studies)
- Contraindications to capsaicin including intolerance to chili or burns or wounds at the application site
- Assessed as unable to cooperate as required by the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aalborg University
Gistrup, Denmark, 9260
Actively Recruiting
Research Team
S
Silvia Lo Vecchio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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