Study of How Uterine Fluid Is Absorbed in Early Pregnancy in Women Aged 18 to 45

What this Trial Is About

Researchers are studying the processes involved in how uterine fluid is absorbed during early pregnancy. This observational study focuses on women aged 18 to 45, including those with endometriosis, infertility, or without these conditions, to better understand the biology of the uterus in these groups. The research is sponsored by Johns Hopkins University and aims to provide insights into the menstrual cycle and uterine health. The study involves two groups 50 women diagnosed with endometriosis and 50 without, as well as 20 women with endometrial lumen fluid and 20 without, all undergoing evaluation possibly during procedures such as IVF. The researchers will analyze the expression levels of selected ion channels and proteins in endometrium tissue samples collected across the menstrual cycle over a five-year period. Participants will undergo biopsies of the endometrium to measure specific proteins and ion channels related to uterine fluid absorption. The main outcome measure is the expression levels of selected ion channels in tissue samples. Secondary measures include protein expression comparisons using immunohistochemistry. The study includes follow-up and monitoring over five years, with assessments of menstrual cycle regularity, body mass index, and infection history to ensure safety and data quality.

Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)