Actively Recruiting
Mechanisms of Visual Restoration After Occipital Stroke
Led by University of Rochester · Updated on 2025-12-04
100
Participants Needed
1
Research Sites
197 weeks
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.
CONDITIONS
Official Title
Mechanisms of Visual Restoration After Occipital Stroke
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects between 21 and 80 years of age
- Residents of the United States or Canada
- Unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter verified by MRI or CT
- Reliable homonymous visual field defects in both eyes large enough to enclose a 5-degree diameter visual stimulus
- Ability to fixate on visual targets reliably for 1000ms with less than 1-degree visual angle jitter
- Willing, able, and competent to provide informed consent
- Own a home computer (desktop or laptop) with reliable internet access
- Normal cognitive abilities and memory to understand and follow instructions in English
- Safe and willing to undergo MRI scans
You will not qualify if you...
- Past or present ocular disease affecting visual acuity
- Best-corrected visual acuity worse than 20/40 in either eye
- Documented or suspected damage to the dorsal Lateral Geniculate Nucleus
- Diffuse whole-brain degenerative processes
- History of traumatic brain injury
- Other brain damage interfering with training or outcome measures
- Oculomotor defects impairing stable fixation
- History of drug or alcohol abuse
- Currently taking neuroactive medications impacting training
- Cognitive, memory, or seizure disorders
- One-sided attentional neglect
- Inability or lack of competence to perform visual training exercises
- Contraindications to MRI (e.g., aneurysm clips, implanted devices, metal shrapnel, morbid obesity, claustrophobia)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
E
Evan Burr, BA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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