Study of Brain Changes and Visual Training Effects After Occipital Stroke in Adults Aged 21 to 80

What this Trial Is About

Researchers are studying the effects of damage to the early visual cortex caused by unilateral stroke or similar injury and how visual training interventions may influence the structure and function of the remaining visual system. The goal is to better understand the consequences of permanent visual cortex damage and how visual training might restore perception in affected individuals. This observational study collects detailed brain imaging data to investigate these questions. Participants include adults aged 21 to 80 who have experienced stroke or stroke-like damage to the primary visual cortex or its immediate afferent white matter. The study groups consist of individuals with cortical blindness due to such damage and control subjects with no history of neurological disorders. The main intervention involves functional MRI scans to assess brain structure and visual responses before and after a period of visual training, with multiple visits scheduled for data collection. During the study, participants will undergo brain imaging to identify damaged visual areas and evaluate visual responses at baseline and following visual training. Assessments include visual field testing and fixation ability checks, along with cognitive and memory evaluations to ensure participants can complete training at home independently. Data collection occurs across several visits, including optional ones, to monitor changes over time. Safety monitoring includes ensuring participants are safe for MRI scans. The total duration and frequency of visits vary based on individual study schedules.

Mechanisms of Visual Restoration After Occipital Stroke