Study Comparing Modified and Conventional Vertical Sleeve Gastrectomy to Reduce Acid Reflux After Surgery and Improve Quality of Life

What this Trial Is About

Researchers are evaluating a surgical innovation designed to reduce gastroesophageal reflux disease GERD in patients who have undergone vertical sleeve gastrectomy VSG, a common bariatric surgery for obesity. The trial compares a modified vertical sleeve gastrectomy mVSG procedure to the conventional version cVSG to see if it lowers acid exposure time in the esophagus and improves quality of life over 6 to 12 months after surgery. Participants will be randomly assigned to receive either the modified VSG, which preserves gastric sling fibers and restores the gastroesophageal flap valve, or the conventional VSG procedure. The study focuses on testing these two surgical methods in parallel groups to understand their impact on GERD symptoms and esophageal function. Throughout the trial, participants will undergo several assessments before and after surgery, including the Bravo pH test to measure acid exposure, esophageal manometry to evaluate esophageal pressures, imaging tests to examine the gastroesophageal flap valve, and quality of life questionnaires. Researchers will monitor these outcomes at baseline and again between 6 and 12 months after surgery to determine the effects of each surgical method on GERD and patient well-being.

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)