Actively Recruiting
Mechanistic Effect of Walnut Consumption on Sleep Quality
Led by Columbia University · Updated on 2025-07-31
24
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
Sponsors
C
Columbia University
Lead Sponsor
U
United States Department of Agriculture (USDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Poor sleep quality is very common in modern society. Walnuts contain many nutrients that may be helpful for sleep, including melatonin and polyphenols. Some studies show that eating foods high in melatonin and polyphenols improves sleep quality, but walnuts have not been studied specifically. This study proposes to test if eating walnuts improves sleep compared to a food that lacks these sleep-promoting factors. The investigators expect that walnut consumption for 4 days will increase melatonin levels and lead to better sleep quality compared to a high-carbohydrate, high-sugar food. The study will enroll middle-aged and older adults with sleep complaints to participate in this study. Each person will eat the two different foods for 4 days each in random order. The 4-day periods will be separated by at least 2-3 weeks. Sleep quality will be measured by questionnaire and with a wrist monitor every day. The investigators will also do a sleep study using electroencephalography (EEG) on night 3 and take measures of circadian physiology (natural body rhythms) in the laboratory on day 4 (including overnight) by measuring body temperature and blood and urine melatonin. The study findings may provide new options to improve sleep health from increased walnut consumption.
CONDITIONS
Official Title
Mechanistic Effect of Walnut Consumption on Sleep Quality
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Equal numbers of men and post-menopausal women (12 males and 12 females)
- Equal numbers of individuals with normal weight (BMI 18.5-24.9) and overweight (BMI 25-29.9)
- Participants must self-report poor sleep quality with a Pittsburgh Sleep Quality Index score greater than 5
You will not qualify if you...
- Diagnosed sleep disorder
- Smoking or excessive caffeine intake (over 300 mg/day)
- Shift work
- Chronic pain
- Diagnosis of chronic diseases such as uncontrolled hypertension, pre-diabetes, type 2 diabetes, chronic kidney disease, chronic obstructive pulmonary disease
- Autoimmune diseases
- Cardiovascular event or cancer within the past 24 months
- Psychiatric or neurologic disease or disorder
- High risk or diagnosis of sleep apnea, chronic insomnia, restless leg syndrome, or narcolepsy
- Use of medications that affect CYP1A2 enzymes
- Allergy or intolerance to nuts or unwillingness to eat study foods
AI-Screening
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Trial Site Locations
Total: 1 location
1
Columbia University Irving Medical Center
New York, New York, United States, 10032
Actively Recruiting
Research Team
J
Joseariel Romero
CONTACT
C
Claudia Dreyer, BS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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