Actively Recruiting
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
Led by University of Florida · Updated on 2025-10-01
110
Participants Needed
1
Research Sites
292 weeks
Total Duration
On this page
Sponsors
U
University of Florida
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The current study is a mechanistic study to evaluate working memory gains from application of transcranial direct current stimulation (tDCS) in older adults with mild cognitive impairments (MCI) compared to cognitively healthy control
CONDITIONS
Official Title
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 to 95 years
- Montreal Cognitive Assessment (MoCA) score of 18 or higher, adjusted for education
- Able to receive electrical stimulation
- Able to understand conversational speech
- Adequate motor skills to operate a computer mouse and click buttons while in the scanner
- Able to participate in the intervention and attend training sessions
You will not qualify if you...
- Unable to provide informed consent
- Contraindications to MRI (e.g., ferrous metal implants, heart valve prosthesis, claustrophobia, implanted neurostimulation devices, defibrillator, pacemaker)
- Left-handed or left hand dominant
- History of neurological disorders, seizures, psychiatric disorders, traumatic brain injury, or stroke involving large vessels
- Terminal illness with life expectancy under 12 months
- Brain tumor, malformation, or foreign objects in the brain
- Active cancer treatment except for skin cancer
- Currently taking medications that affect brain excitability (GABAergic, glutamatergic, calcium or sodium channel blockers)
- Severe hearing loss or speech disorder preventing communication
- Severe sensory impairment
- Unable to communicate in English
- Severe visual impairment preventing assessment or intervention completion
- Physical impairments that prevent motor responses or lying still for an hour in the scanner
- Moderate-to-severe depression as indicated by a score of 10 or higher on the Geriatric Depression Scale (GDS)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
A
Aprinda I Queen, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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