Actively Recruiting
Mechanistic Study of Personalized rTMS in Chronic Pain
Led by Aalborg University · Updated on 2026-05-07
90
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Previous research has demonstrated that repetitive magnetic brain stimulation can be an effective adjunctive treatment for several conditions, including chronic pain. However, current stimulation protocols are typically standardized and do not account for individual variability in brain function. This uniform, one-size-fits-all approach results in only about 40% of patients experiencing meaningful clinical benefit, while the remainder show little to no improvement. To address this limitation, the present study will investigate how magnetic stimulation can be tailored to individuals with chronic pain. By analyzing each participant's brain signals prior to treatment, we aim to personalize stimulation parameters to better match individual neural characteristics and potentially enhance therapeutic outcomes. The design of this study builds directly on the findings of a previous clinical trial.
CONDITIONS
Official Title
Mechanistic Study of Personalized rTMS in Chronic Pain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of chronic pain most days for more than 3 months
- Mean pain intensity between 3 and 9 on a 0-10 scale
- Ability to speak and understand English or Danish
You will not qualify if you...
- Pregnant or breastfeeding
- Current uncontrolled major depression as main diagnosis
- Current history of substance abuse
- Inability to cooperate or understand the protocol or complete questionnaires
- Contraindications to TMS (epilepsy, cranial implanted ferromagnetic devices, facial metal tattoos or permanent makeup)
- Unable to answer the Transcranial Magnetic Stimulation Adult Safety Screen questionnaire
- Participation in other research protocols within 1 month before inclusion
AI-Screening
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Trial Site Locations
Total: 1 location
1
Aalborg University
Gistrup, Denmark, 9260
Actively Recruiting
Research Team
E
Enrico De Martino, MD, PhD
CONTACT
D
Daniel Ciampi De Andrade, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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