Actively Recruiting
Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein
Led by Antonio Eduardo Zerati · Updated on 2026-05-01
50
Participants Needed
1
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study compares two minimally invasive treatments for varicose veins in the legs, specifically the great saphenous vein. Varicose veins can cause symptoms such as leg pain, swelling, and skin changes. One commonly used treatment is foam sclerotherapy, where a special foam is injected into the vein to close it. This method is simple and allows patients to return quickly to their daily activities, but sometimes the vein can reopen, requiring additional treatments. Another option is mechanochemical ablation, which combines a small device with a medication to close the vein. This method also allows for quick recovery and may have a lower chance of the vein reopening. In this study, 50 patients with varicose veins will be randomly assigned to receive one of these two treatments. Doctors will follow patients over time to evaluate: How well the treated vein stays closed Improvement in quality of life Pain during the procedure Possible complications All procedures are performed with local anesthesia, and additional small varicose veins are treated at the same time.
CONDITIONS
Official Title
Mechanochemical Ablation Versus Ultrasound-Guided Foam Sclerotherapy of the Great Saphenous Vein
Who Can Participate
Eligibility Criteria
You may qualify if you...
- CEAP Classification C2, 3 or 4
- Insufficient great saphenous vein measuring 6-12 mm in the mid-thigh on Doppler ultrasound.
You will not qualify if you...
- Allergy to sclerosing substances
- Deep venous thrombosis, stroke, or pulmonary embolism
- Local or generalized infection at the sclerotherapy site
- Prolonged immobilization
- Asymptomatic patent foramen ovale
- Pregnancy
- Occlusive peripheral arterial disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Hospital da Clínicas da FMUSP
São Paulo, São Paulo, Brazil
Actively Recruiting
Research Team
A
Antonio Zerati, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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