Actively Recruiting
MeDex: No Perioperative Dexamethasone in Brain Metastases
Led by University of Louisville · Updated on 2026-05-11
35
Participants Needed
1
Research Sites
74 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Perioperative treatment of newly diagnosed cancer patients with brain metastasis without dexamethasone (Dex).
CONDITIONS
Official Title
MeDex: No Perioperative Dexamethasone in Brain Metastases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- New brain tumor(s) detected on imaging
- Suspicious or confirmed visceral mass(es) for cancer
- Patients with suspicious lung mass and no prior diagnosis must have lung biopsy before brain metastasis surgery
- No contraindications for brain surgery (craniotomy)
- Age 18 years or older
- ECOG performance status of 2 or less (ambulatory more than 50% of waking hours)
- Midline brain shift on MRI 10 mm or less
- Planned craniotomy to remove more than 75% of the enhancing tumor mass (surgeon's judgment)
You will not qualify if you...
- Presence of brain metastases not suitable for removal that are larger than 2 cm each
- More than 4 brain metastases not suitable for removal that are larger than 2 cm each
- Prior treatment with laser interstitial thermal therapy (LITT)
- High suspicion of primary CNS lymphoma
- Diagnosis of small cell lung carcinoma
- Any prior use of dexamethasone
- Steroid use within the past month
- Medical condition requiring steroid treatment
- Stage 4 chronic kidney disease (glomerular filtration rate less than 30)
- Pregnant or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Louisville Hospital
Louisville, Kentucky, United States, 40202
Actively Recruiting
Research Team
A
A Mistry, MD
CONTACT
M
M Kaufman, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
OTHER
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here