Actively Recruiting
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Led by AstraZeneca · Updated on 2026-04-28
825
Participants Needed
178
Research Sites
262 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a phase III, randomized, open-label, multicenter, global study to determine the efficacy and safety of Volrustomig (MEDI5752) + Carboplatin + Pemetrexed vs the investigator's choice of platinum + Pemetrexed or Nivolumab + Ipilimumab in participants with unresectable pleural mesothelioma.
CONDITIONS
Official Title
MEDI5752 in Combination With Carboplatin Plus Pemetrexed in Unresectable Pleural Mesothelioma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be 18 years or older at screening
- Histologically confirmed pleural mesothelioma with known histology type
- Advanced disease that cannot be treated with curative surgery
- WHO/ECOG performance status of 0 or 1 without deterioration in past two weeks
- Measurable disease according to modified RECIST1.1
- Adequate bone marrow and organ function at baseline
You will not qualify if you...
- Conditions interfering with investigational product evaluation or safety interpretation as judged by investigator
- Active or prior autoimmune or inflammatory disorders
- History of another primary cancer except allowed exceptions
- Uncontrolled intercurrent illness
- Uncontrolled infections including tuberculosis, hepatitis B or C, or HIV
- Receiving concurrent chemotherapy, radiotherapy, investigational, biologic, or hormonal cancer therapy
- Untreated or progressive central nervous system metastatic disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 178 locations
1
Research Site
Phoenix, Arizona, United States, 85054
Withdrawn
2
Research Site
Duarte, California, United States, 91010
Withdrawn
3
Research Site
Santa Rosa, California, United States, 95403
Actively Recruiting
4
Research Site
Aurora, Colorado, United States, 80045
Actively Recruiting
5
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
6
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
7
Research Site
Chicago, Illinois, United States, 60637
Actively Recruiting
8
Research Site
Baltimore, Maryland, United States, 21231
Actively Recruiting
9
Research Site
Rochester, Minnesota, United States, 55905
Actively Recruiting
10
Research Site
St Louis, Missouri, United States, 63110
Actively Recruiting
11
Research Site
East Brunswick, New Jersey, United States, 08816
Withdrawn
12
Research Site
Commack, New York, United States, 11725
Actively Recruiting
13
Research Site
Valhalla, New York, United States, 10595
Actively Recruiting
14
Research Site
Cleveland, Ohio, United States, 44111
Withdrawn
15
Research Site
Cleveland, Ohio, United States, 44124
Withdrawn
16
Research Site
Cleveland, Ohio, United States, 44195
Withdrawn
17
Research Site
Columbus, Ohio, United States, 43210
Actively Recruiting
18
Research Site
Independence, Ohio, United States, 44131
Withdrawn
19
Research Site
Portland, Oregon, United States, 97213
Actively Recruiting
20
Research Site
Portland, Oregon, United States, 97225
Actively Recruiting
21
Research Site
Portland, Oregon, United States, 97239
Withdrawn
22
Research Site
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
23
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
24
Research Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
25
Research Site
Chermside, Australia, 4032
Active, Not Recruiting
26
Research Site
Clayton, Australia, 3168
Active, Not Recruiting
27
Research Site
Melbourne, Australia, 3000
Active, Not Recruiting
28
Research Site
Nedlands, Australia, 6009
Active, Not Recruiting
29
Research Site
Westmead, Australia, 2145
Active, Not Recruiting
30
Research Site
Anderlecht, Belgium, 1070
Active, Not Recruiting
31
Research Site
Antwerp, Belgium, 2020
Active, Not Recruiting
32
Research Site
Ghent, Belgium, 9000
Completed
33
Research Site
Hasselt, Belgium, 3500
Active, Not Recruiting
34
Research Site
Leuven, Belgium, 3000
Withdrawn
35
Research Site
Sint-Niklaas, Belgium, 9100
Active, Not Recruiting
36
Research Site
Barretos, Brazil, 14784-400
Active, Not Recruiting
37
Research Site
Fortaleza, Brazil, 60336-045
Active, Not Recruiting
38
Research Site
João Pessoa, Brazil, 58013-140
Withdrawn
39
Research Site
Porto Alegre, Brazil, 91350-200
Active, Not Recruiting
40
Research Site
Rio de Janeiro, Brazil, 22281-100
Active, Not Recruiting
41
Research Site
Santo André, Brazil, 09060-650
Active, Not Recruiting
42
Research Site
São Paulo, Brazil, 01246-000
Active, Not Recruiting
43
Research Site
Edmonton, Alberta, Canada, T6G 1Z2
Active, Not Recruiting
44
Research Site
Hamilton, Ontario, Canada, L8V 1C3
Withdrawn
45
Research Site
London, Ontario, Canada, N6A 5W9
Withdrawn
46
Research Site
Ottawa, Ontario, Canada, K1H 8L6
Active, Not Recruiting
47
Research Site
Toronto, Ontario, Canada, M5G 1X6
Active, Not Recruiting
48
Research Site
Montreal, Quebec, Canada, H2X 0C1
Active, Not Recruiting
49
Research Site
Québec, Quebec, Canada, G1V 4G5
Active, Not Recruiting
50
Research Site
Beijing, China, 100142
Active, Not Recruiting
51
Research Site
Beijing, China, 100210
Active, Not Recruiting
52
Research Site
Changchun, China, 130021
Withdrawn
53
Research Site
Changsha, China, 410013
Active, Not Recruiting
54
Research Site
Chengdu, China, 610042
Active, Not Recruiting
55
Research Site
Chongqing, China, 400030
Withdrawn
56
Research Site
Guangzhou, China, 510100
Active, Not Recruiting
57
Research Site
Hangzhou, China, 310022
Active, Not Recruiting
58
Research Site
Harbin, China, 150049
Active, Not Recruiting
59
Research Site
Kunming, China, 650118
Active, Not Recruiting
60
Research Site
Lanzhou, China, 730000
Active, Not Recruiting
61
Research Site
Nanchang, China, 330006
Withdrawn
62
Research Site
Ningbo, China, 315100
Active, Not Recruiting
63
Research Site
Qingdao, China, 266003
Active, Not Recruiting
64
Research Site
Shandong, China
Active, Not Recruiting
65
Research Site
Shanghai, China, 200032
Active, Not Recruiting
66
Research Site
Shenyang, China, 110044
Active, Not Recruiting
67
Research Site
Taiyuan, China, 030000
Active, Not Recruiting
68
Research Site
Taiyuan, China, 030032
Active, Not Recruiting
69
Research Site
Tianjin, China, 300050
Active, Not Recruiting
70
Research Site
Tianjin, China, 300060
Active, Not Recruiting
71
Research Site
Wuhan, China, 430030
Active, Not Recruiting
72
Research Site
Xi'an, China, 710061
Completed
73
Research Site
Zhengzhou, China, 450008
Active, Not Recruiting
74
Research Site
Zhengzhou, China, 450052
Active, Not Recruiting
75
Research Site
Aarhus N, Denmark, 8200
Active, Not Recruiting
76
Research Site
Copenhagen, Denmark, 2100
Active, Not Recruiting
77
Research Site
Brest, France, 29200
Completed
78
Research Site
Créteil, France, 94010
Active, Not Recruiting
79
Research Site
Le Mans, France, 72037
Active, Not Recruiting
80
Research Site
Lille, France, 59037
Active, Not Recruiting
81
Research Site
Lyon, France, 69373
Active, Not Recruiting
82
Research Site
Marseille, France, 13015
Active, Not Recruiting
83
Research Site
Montpellier, France, 34298
Active, Not Recruiting
84
Research Site
Paris, France, 75877
Active, Not Recruiting
85
Research Site
Rouen, France, 76031
Active, Not Recruiting
86
Research Site
Saint-Herblain, France, 44800
Active, Not Recruiting
87
Research Site
Strasbourg, France, 67091
Active, Not Recruiting
88
Research Site
Toulouse, France, 31059
Active, Not Recruiting
89
Research Site
Berlin, Germany, 13125
Actively Recruiting
90
Research Site
Berlin, Germany, 14109
Actively Recruiting
91
Research Site
Bochum, Germany, 44791
Actively Recruiting
92
Research Site
Cologne, Germany, 51109
Actively Recruiting
93
Research Site
Essen, Germany, 45122
Actively Recruiting
94
Research Site
Essen, Germany, 45130
Withdrawn
95
Research Site
Gauting, Germany, 82131
Actively Recruiting
96
Research Site
Georgsmarienhütte, Germany, 49124
Actively Recruiting
97
Research Site
Großhansdorf, Germany, 22927
Actively Recruiting
98
Research Site
Hamburg, Germany, 21075
Actively Recruiting
99
Research Site
Heidelberg, Germany, 69126
Actively Recruiting
100
Research Site
Kiel, Germany, 24105
Actively Recruiting
101
Research Site
Münster, Germany, 48153
Actively Recruiting
102
Research Site
Regensburg, Germany, 93049
Actively Recruiting
103
Research Site
Alessandria, Italy, 15100
Active, Not Recruiting
104
Research Site
Bari, Italy, 70124
Active, Not Recruiting
105
Research Site
Bergamo, Italy, 24125
Active, Not Recruiting
106
Research Site
Milan, Italy, 20141
Active, Not Recruiting
107
Research Site
Monza, Italy, 20052
Active, Not Recruiting
108
Research Site
Orbassano, Italy, 10043
Active, Not Recruiting
109
Research Site
Padova, Italy, 35128
Active, Not Recruiting
110
Research Site
Parma, Italy, 43100
Active, Not Recruiting
111
Research Site
Rozzano, Italy, 20089
Active, Not Recruiting
112
Research Site
Varese, Italy, 21100
Active, Not Recruiting
113
Research Site
Amagasaki-shi, Japan, 660-8550
Active, Not Recruiting
114
Research Site
Hakodate-shi, Japan, 040-8611
Active, Not Recruiting
115
Research Site
Hiroshima, Japan, 734-8551
Active, Not Recruiting
116
Research Site
Kitaadachi-gun, Japan, 362-0806
Active, Not Recruiting
117
Research Site
Kitakyushu-shi, Japan, 807-8555
Active, Not Recruiting
118
Research Site
Matsuyama, Japan, 791-0280
Active, Not Recruiting
119
Research Site
Nagoya, Japan, 466-8560
Active, Not Recruiting
120
Research Site
Nishinomiya-shi, Japan, 663-8501
Active, Not Recruiting
121
Research Site
Okayama, Japan, 702-8055
Active, Not Recruiting
122
Research Site
Osakasayama-shi, Japan, 589-8511
Active, Not Recruiting
123
Research Site
Tokyo, Japan, 104-0045
Active, Not Recruiting
124
Research Site
Ube-shi, Japan, 755-0241
Active, Not Recruiting
125
Research Site
Amsterdam, Netherlands, 1066CX
Active, Not Recruiting
126
Research Site
Eindhoven, Netherlands, 5623EJ
Active, Not Recruiting
127
Research Site
Rotterdam, Netherlands, 3015 GD
Active, Not Recruiting
128
Research Site
Lørenskog, Norway, 1478
Completed
129
Research Site
Oslo, Norway, 450
Active, Not Recruiting
130
Research Site
Bydgoszcz, Poland, 85-796
Withdrawn
131
Research Site
Bystra, Poland, 43-360
Active, Not Recruiting
132
Research Site
Olsztyn, Poland, 10-357
Active, Not Recruiting
133
Research Site
Poznan, Poland, 60-569
Active, Not Recruiting
134
Research Site
Rzeszów, Poland, 35-241
Withdrawn
135
Research Site
Warsaw, Poland, 02-781
Active, Not Recruiting
136
Research Site
Cape Town, South Africa, 7570
Active, Not Recruiting
137
Research Site
eManzimtoti, South Africa, 4126
Active, Not Recruiting
138
Research Site
Johannesburg, South Africa, 2013
Active, Not Recruiting
139
Research Site
Johannesburg, South Africa, 2193
Active, Not Recruiting
140
Research Site
Kimberly, South Africa, 8301
Active, Not Recruiting
141
Research Site
Polokwane, South Africa, 0700
Withdrawn
142
Research Site
Pretoria, South Africa, 0002
Active, Not Recruiting
143
Research Site
Pretoria, South Africa, 0081
Active, Not Recruiting
144
Research Site
Cheongju-si, South Korea, 28644
Withdrawn
145
Research Site
Seoul, South Korea, 03080
Active, Not Recruiting
146
Research Site
Seoul, South Korea, 06351
Actively Recruiting
147
Research Site
Seoul, South Korea, 06591
Actively Recruiting
148
Research Site
Ulsan, South Korea, 44033
Withdrawn
149
Research Site
Barakaldo, Spain, 48903
Active, Not Recruiting
150
Research Site
Barcelona, Spain, 8035
Active, Not Recruiting
151
Research Site
Madrid, Spain, 28041
Active, Not Recruiting
152
Research Site
Oviedo, Spain, 33011
Active, Not Recruiting
153
Research Site
Baden, Switzerland, CH-5405
Active, Not Recruiting
154
Research Site
Basel, Switzerland, 4031
Active, Not Recruiting
155
Research Site
Bern, Switzerland, 3010
Active, Not Recruiting
156
Research Site
Fribourg, Switzerland, 1700
Active, Not Recruiting
157
Research Site
Sankt Gallen, Switzerland, 9007
Active, Not Recruiting
158
Research Site
Kaohsiung City, Taiwan, 80756
Active, Not Recruiting
159
Research Site
Taichung, Taiwan, 40705
Active, Not Recruiting
160
Research Site
Tainan, Taiwan, 70403
Withdrawn
161
Research Site
Taipei, Taiwan, 10002
Active, Not Recruiting
162
Research Site
Taoyuan, Taiwan, 333
Withdrawn
163
Research Site
Adana, Turkey (Türkiye), 01060
Withdrawn
164
Research Site
Ankara, Turkey (Türkiye), 06280
Active, Not Recruiting
165
Research Site
Ankara, Turkey (Türkiye), 06800
Active, Not Recruiting
166
Research Site
Diyarbakır, Turkey (Türkiye), 21280
Active, Not Recruiting
167
Research Site
Izmir, Turkey (Türkiye), 35110
Active, Not Recruiting
168
Research Site
Cambridge, United Kingdom, CB20QQ
Active, Not Recruiting
169
Research Site
Cardiff, Wales, United Kingdom, CF5 6NF
Withdrawn
170
Research Site
Leeds, United Kingdom, LS9 7TF
Active, Not Recruiting
171
Research Site
Leicester, United Kingdom, LE1 5WW
Active, Not Recruiting
172
Research Site
London, United Kingdom, NW1 2PG
Active, Not Recruiting
173
Research Site
London, United Kingdom, SE1 9RT
Active, Not Recruiting
174
Research Site
London, United Kingdom, SW3 6JJ
Active, Not Recruiting
175
Research Site
Manchester, United Kingdom, M23 9LT
Active, Not Recruiting
176
Research Site
Newcastle upon Tyne, United Kingdom, NE2 4HH
Active, Not Recruiting
177
Research Site
Portsmouth, United Kingdom, PO6 3LY
Active, Not Recruiting
178
Research Site
Taunton, United Kingdom, TA1 5DA
Active, Not Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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