Actively Recruiting
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
Led by University of California, San Francisco · Updated on 2025-08-29
160
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
Sponsors
U
University of California, San Francisco
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized controlled trial in healthy controls (HC) and patients with schizophrenia (SZ) aims to examine 1) the underlying cognitive and neural cause of self-agency deficits in SZ; 2) the responsiveness to a novel navigated repetitive transcranial magnetic stimulation (nrTMS) target in the medial/superior prefrontal cortex (mPFC); and 3) how modulation of mPFC activity impacts the larger self-agency network to mediate changes in self-agency judgments. Our overall hypothesis is that increased mPFC excitability by active high-frequency nrTMS in HC and SZ will induce behavioral improvements in self-agency and neural changes in the larger self-agency network that will generalize to improvements in overall cognition, symptoms and daily functioning, and will likely lead to the development of new effective neuromodulation therapies in patients with schizophrenia.
CONDITIONS
Official Title
Medial-prefrontal Enhancement During Schizophrenia Systems Imaging
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Good general physical health
- English is first language
- No neurological disorder
- Meets MRI criteria
- No current alcohol or substance use disorder
- Schizophrenia diagnosis of any illness duration (for schizophrenia participants)
- Clinical stability with at least 12 weeks outpatient status
- Stable low to moderate dose of antipsychotic medication for at least 4 weeks (less than 1000 mg chlorpromazine equivalents), plus stable doses of other psychotropic medications (for schizophrenia participants)
You will not qualify if you...
- Implanted metallic parts or electronic devices
- Pregnant or trying to become pregnant
- Any condition preventing voluntary informed consent
- Scalp wounds or infections
- Claustrophobia preventing MRI
- Ongoing seizures
- Neurological disorder
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UCSF
San Francisco, California, United States, 94143
Actively Recruiting
Research Team
K
Karuna Subramaniam, Ph.D
CONTACT
M
Miriam Mathew, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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