Actively Recruiting
Led by Loma Linda University · Updated on 2026-01-30
32
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are evaluating how muscle relaxation during surgery can be monitored using two different nerves in the arm: the ulnar nerve and the median nerve. Muscle relaxants are commonly used in surgery, and the ulnar nerve is typically used to assess the depth of muscle relaxation. This study aims to compare responses to muscle relaxants between the ulnar nerve and the median nerve to see if the median nerve provides similar information. This is a randomized controlled trial where electrodes are placed on both arms of patients undergoing surgery that requires muscle relaxation with non-depolarizing neuromuscular blockers. One arm will have electrodes stimulating the ulnar nerve, while the other arm will have electrodes stimulating the median nerve. The location of the median nerve stimulation is randomized to either the dominant or non-dominant hand. The study will compare the muscle responses and recovery times after administration of muscle relaxants and reversal agents. Participants will be adults aged 18 to 75 years scheduled for elective surgery under general anesthesia expected to last at least 1.5 hours. During surgery, nerve stimulation and electromyography will be used to monitor muscle responses at both nerve sites. Researchers will measure the timing of muscle response after muscle relaxant administration and recovery after reversal medication. The study will assess differences in muscle relaxation monitoring between the two nerves and monitor safety throughout the process.
CONDITIONS
Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery (at least 1.5 hours)
Participants undergoing surgery receive neuromuscular transmission monitoring using electrodes placed on both the ulnar and median nerves to compare responses to non-depolarizing neuromuscular blockade during the procedure.
1 visit (in-person during surgery)
Duration - Up to 30 minutes after surgery
Participants are observed for recovery from neuromuscular blockade with monitoring continuing until the return of muscle function post-surgery.
1 visit (in-person post-surgery)
Total: 1 location
1
Loma Linda University Troesch Medical Center
Loma Linda, California, United States, 92354
Actively Recruiting
M
Melissa D McCabe, MD, MSCR
M
Michael Benggon, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Have more questions? Get in touch with our team for quick support
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here
Hajime Iwasaki, Mai Yamamoto, Hanae Sato...
https://pubmed.ncbi.nlm.nih.gov/35061641Ricardo Ortiz, Ritsaart F Westenberg, Christopher G Langhammer...
https://pubmed.ncbi.nlm.nih.gov/31044121Philippe Duvaldestin, Karel Kuizenga, Vera Saldien...
https://pubmed.ncbi.nlm.nih.gov/19933538Hee Jong Lee, Kyo Sang Kim, Jae Chul Shim...
https://pubmed.ncbi.nlm.nih.gov/21716963A Bowdle, L Bussey, K Michaelsen...
https://pubmed.ncbi.nlm.nih.gov/31617199