Actively Recruiting
MEdical Treatment in Idiopathic Ventricular Fibrillation Patients
Led by Bo Gregers Winkel · Updated on 2026-02-12
218
Participants Needed
2
Research Sites
921 weeks
Total Duration
On this page
Sponsors
B
Bo Gregers Winkel
Lead Sponsor
T
The Novo Nordisk Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
A person who has experienced a cardiac arrest with no apparent cause is at risk of having recurrent cardiac arrest. Hence an implantable cardioverter-defibrillator (ICD) is recommended on empirical grounds. Today, there is no uniform way of approaching prevention of recurrence in idiopathic ventricular fibrillation (IVF) patients, beside ICD implantation. Better reatment and risk stratification tools are needed Medical treatment in these patients has never been assessed systematically, but at least some patients with no apparent diagnosis are on betablocker treatment. It is not known if low-doselow dose betablocker treatment is beneficial in these patients. This study investigates the effect of betablocker treatment to reduce arrhythmic burden in IVF patients. No predictors for appropriate ICD therapy have been identified in patients with IVF. It is also explored if toxicological and/or genetic profiles, together with in depth machine learning simulation data on repolarization patterns from IVF-ECGs compared to controls, can be used as risk stratification tools. Lastly, QOL in IVF patients and the impact of beta blocker treatment will be investigated.
CONDITIONS
Official Title
MEdical Treatment in Idiopathic Ventricular Fibrillation Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Resuscitated out-of-hospital cardiac arrest patients admitted to participating hospitals
- Age 18 years or older
- Cardiac arrest suspected to be caused by a heart condition
You will not qualify if you...
- Out-of-hospital cardiac arrest patients with ischemic heart disease
- Cardiac arrest due to an obvious non-cardiac cause
- Congenital heart disease
- Unable to speak or understand Danish
- Foreigners
AI-Screening
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Trial Site Locations
Total: 2 locations
1
The Heart Center, Rigshospitalet
Copenhagen, Dr., Denmark, 2100
Actively Recruiting
2
Odense University Hospital
Odense, Denmark, 5000
Not Yet Recruiting
Research Team
B
Bo G Winkel, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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