Actively Recruiting
Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin
Led by Mst.Sumyara Khatun · Updated on 2026-01-07
60
Participants Needed
1
Research Sites
73 weeks
Total Duration
On this page
Sponsors
M
Mst.Sumyara Khatun
Lead Sponsor
B
Bangladesh Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Women with polycystic ovary syndrome with HOMA-IR \>2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B (Metformin 500mg). Each group will be contained 30 selected patients. Group B:Tab. Metformin (500mg) once daily for 7days followed by twice daily for next 7 days followed by thrice daily for next 10 weeks. Outcome variables will be measured after three months, will be meticulously recorded for analysis and comparison.
CONDITIONS
Official Title
Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with polycystic ovary syndrome (PCOS) according to Rotterdam criteria
- Female aged 18 to 35 years
- Insulin resistance with HOMA-IR greater than 2.6
You will not qualify if you...
- Body mass index (BMI) less than or equal to 18.5 or greater than or equal to 30 kg/m2
- Uncontrolled endocrine disorders such as diabetes mellitus, hypothyroidism, or hyperprolactinemia
- Known medical diseases including kidney, liver, or heart conditions
- Use of medications affecting insulin resistance (Metformin, Myo-inositol, Pioglitazone) within the last three months
- Allergy or hypersensitivity to melatonin
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bangladesh Medical University
Dhaka, Shahbag, Bangladesh, 1000
Actively Recruiting
Research Team
M
Mst.Sumyara Khatun, MS
CONTACT
F
Farzana Rahman, MBBS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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