Effect of Melatonin Supplementation Combined with Exercise on Women Over 60 Who Have Had Breast Cancer in Soria, Spain

What this Trial Is About

This research aims to evaluate the effects of melatonin supplementation combined with a physical training program on women over 60 years old who have previously had breast cancer. Breast cancer remains a leading cancer in women, and treatments often cause muscle loss, fatigue, reduced physical function, and lower quality of life. Melatonin, a hormone with multiple protective roles including anti-cancer actions, is being studied here for its potential to improve these complications when taken alongside exercise. Participants are randomly assigned to one of two groups one receives 6 mg of melatonin daily two capsules at bedtime for 10 weeks, and the other receives a matching placebo. Both groups follow a physical activity program adapted to their age and abilities. The study is double-blind, meaning neither participants nor researchers know who receives melatonin or placebo during the trial period. During the study, researchers will assess muscle damage markers, hormone levels, antioxidants, proteins related to exercise effects, physical performance tests, body measurements, and quality of life using questionnaires. These measurements are taken at the start and after 10 weeks of supplementation. The study monitors overall health, physical function, and wellbeing to understand melatonins impact in this population, with participation lasting about 10 weeks.

Melatonin Supplementation and Exercise Program in Breast Cancer Women