How We Do It: Postoperative Pain Control in Mohs Micrographic Surgery.
Tyler Evans, Thomas A Nicholas, Adam V Sutton...
https://pubmed.ncbi.nlm.nih.gov/31809346/Actively Recruiting
Led by University of Oklahoma · Updated on 2025-12-15
300
Participants Needed
1
Research Sites
8 weeks
Total Duration
This research aims to explore alternative methods for managing postoperative pain in patients undergoing Mohs micrographic surgery, a precise technique for removing certain skin cancers. The study focuses on comparing different pain control options to improve comfort and overall well-being after surgery. Researchers hope to provide better information to the Mohs surgery community and offer patients a potential new choice of pain medication with fewer side effects than standard options. Participants will be randomly assigned to one of three groups one group will receive a single dose of Meloxicam 7.5 mg followed by acetaminophen 500 mg as needed, another group will receive a single dose of Meloxicam 15 mg followed by acetaminophen 500 mg as needed, and the control group will take a single dose of acetaminophen 500 mg followed by alternating ibuprofen 200 mg and acetaminophen 500 mg every three hours, which is the current standard of care. Meloxicam will be given orally right after the surgical wound closure. During the study, participants will complete surveys about their pain levels and satisfaction with pain control. Researchers will monitor pain from enrollment until suture removal or wound check, typically between 7 to 21 days post-surgery. The study will evaluate how well Meloxicam controls pain compared to the standard pain medications. Safety and patient experience will be carefully observed throughout the trial period, which runs until August 2026.
CONDITIONS
Meloxicam in Mohs Micrographic Surgery
C
Chase Pitchford, MD
L
Landon Hendrickson, MD
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University of Oklahoma
Lead Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Meloxicam 7.5 mg | Standard Acetaminophen and Ibuprofen Regimen | Meloxicam 15 mg |
|---|---|---|---|
| What it is | A single oral dose of 7.5 mg meloxicam taken after wound closure in Mohs surgery for pain control. | Sequential doses of acetaminophen (500mg) and ibuprofen (200mg), alternating every 3 hours after Mohs surgery for postoperative pain control. | A single oral dose of 15 mg meloxicam given after the surgical procedure for pain relief. |
| Role in the trial | Investigational group assessing whether a lower meloxicam dose can manage pain after surgery. | Active comparator representing current pain management used after Mohs surgery. | Investigational group assessing a higher dose of meloxicam as an alternative for postoperative pain. |
| Primary use | Tested as a possible alternative to standard pain management for reducing acute postsurgical pain. | Standard regimen to relieve mild to moderate pain after dermatologic surgery. | Assessed as a higher-dose option for pain management after skin cancer surgery. |
| How it is given or performed | A single 7.5 mg meloxicam tablet is taken by mouth after wound closure on the surgery day. | Oral acetaminophen (500 mg) is combined with oral ibuprofen (200 mg), alternating every 3 hours on the day of surgery and as needed afterward. | A 15 mg meloxicam tablet is given orally after surgery as a one-time dose. |
| Evidence status | Efficacy for surgical pain reduction will be determined by this trial; prior evidence for this specific regimen in Mohs patients is limited. | Established as the usual postoperative pain management with demonstrated efficacy for common Mohs micrographic surgery patients. | Efficacy for acute post-surgical pain after Mohs surgery is not yet established and will be measured by this clinical trial. |
| Important limitations | Potential side effects and comparative efficacy for Mohs postoperative pain are not yet established; suitability in patients with NSAID contraindications is unproven. | Most patients experience mild pain which may require frequent alternating dosing; effectiveness for more severe pain may be limited. | Safety and benefit at 15 mg will be assessed in this study; high-dose NSAIDs may carry increased risk of side effects. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
You may qualify if you...
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 to 21 days
Participants receive a mandatory single dose of Meloxicam or standard pain medication immediately after Mohs surgery closure, followed by as-needed acetaminophen or alternating acetaminophen and ibuprofen for pain control.
1 treatment visit (in-person) upon completion of surgery and medication use as needed at home
Duration - 7 to 21 days
Participants are monitored through suture removal, wound check, or flap takedown to assess postoperative pain and recovery.
1 to 2 follow-up visits depending on surgical closure type
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
3
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Lead Sponsor