Actively Recruiting

Phase 4
Age: 18Years - 110Years
All Genders
ID07200544

Meloxicam for Postoperative Pain in Mohs Micrographic Surgery

Led by University of Oklahoma · Updated on 2025-12-15

300

Participants Needed

1

Research Sites

8 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to explore alternative methods for managing postoperative pain in patients undergoing Mohs micrographic surgery, a precise technique for removing certain skin cancers. The study focuses on comparing different pain control options to improve comfort and overall well-being after surgery. Researchers hope to provide better information to the Mohs surgery community and offer patients a potential new choice of pain medication with fewer side effects than standard options. Participants will be randomly assigned to one of three groups: one group will receive a single dose of Meloxicam 7.5 mg followed by acetaminophen 500 mg as needed, another group will receive a single dose of Meloxicam 15 mg followed by acetaminophen 500 mg as needed, and the control group will take a single dose of acetaminophen 500 mg followed by alternating ibuprofen 200 mg and acetaminophen 500 mg every three hours, which is the current standard of care. Meloxicam will be given orally right after the surgical wound closure. During the study, participants will complete surveys about their pain levels and satisfaction with pain control. Researchers will monitor pain from enrollment until suture removal or wound check, typically between 7 to 21 days post-surgery. The study will evaluate how well Meloxicam controls pain compared to the standard pain medications. Safety and patient experience will be carefully observed throughout the trial period, which runs until August 2026.

CONDITIONS

Brief Title

Meloxicam in Mohs Micrographic Surgery

Who Can Participate

Age: 18Years - 110Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adult patients who consent to participate
  • Undergoing Mohs micrographic surgery at the University of Oklahoma
Not Eligible

You will not qualify if you...

  • Women who are pregnant, suspected to be pregnant, or planning pregnancy during the study
  • Chronic liver disease including hepatitis, cirrhosis, NASH, NAFLD, alcoholic liver disease, hemochromatosis, Wilson's disease
  • Chronic kidney disease stage III or greater
  • Aspirin-sensitive asthma
  • History of chronic NSAID use
  • Patients vulnerable to drug interactions
  • Gastrointestinal bleeds
  • Peptic ulcers
  • Non-English speakers

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - 7 to 21 days

Participants receive a mandatory single dose of Meloxicam or standard pain medication immediately after Mohs surgery closure, followed by as-needed acetaminophen or alternating acetaminophen and ibuprofen for pain control.

1 treatment visit (in-person) upon completion of surgery and medication use as needed at home

Follow-up

Duration - 7 to 21 days

Participants are monitored through suture removal, wound check, or flap takedown to assess postoperative pain and recovery.

1 to 2 follow-up visits depending on surgical closure type

Trial Site Locations

Total: 1 location

1

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States, 73104

Actively Recruiting

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Research Team

C

Chase Pitchford, MD

L

Landon Hendrickson, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

3

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Published Research Related To This Trial

A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction.

Patrick J Sniezek, David G Brodland, John A Zitelli

https://pubmed.ncbi.nlm.nih.gov/21561527

Adverse events associated with mohs micrographic surgery: multicenter prospective cohort study of 20,821 cases at 23 centers.

Murad Alam, Omer Ibrahim, Michael Nodzenski...

https://pubmed.ncbi.nlm.nih.gov/24080866