Actively Recruiting
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
Led by UNC Lineberger Comprehensive Cancer Center · Updated on 2026-05-06
90
Participants Needed
1
Research Sites
199 weeks
Total Duration
On this page
Sponsors
U
UNC Lineberger Comprehensive Cancer Center
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This randomized, placebo-controlled trial aims to assess the feasibility, acceptability, and preliminary efficacy of memantine and the University of Carolina (UNC)'s Get Real \& Heel cancer exercise program (MEM+EX) in addressing cancer-related cognitive impairment (CRCI) and underlying CRCI biomarkers. Ninety stage I-III breast cancer patients during chemotherapy will be randomized into three groups: MEM+EX, memantine, or placebo. The study will evaluate recruitment, retention, adherence, acceptability, cognitive function, brain-derived neurotrophic factor (BDNF), inflammatory markers, and frailty at multiple time points.
CONDITIONS
Official Title
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Age 18 years or older at the time of consent
- Diagnosed with stage I-III breast cancer
- Recommended to receive chemotherapy
- Enrolled before the 3rd cycle of chemotherapy
- Able to speak and understand English
You will not qualify if you...
- Allergy to memantine
- Previous chemotherapy before the current treatment
- Severe cognitive impairment (Blessed Orientation Memory Concentration Test Score greater than or equal to 11)
- Heart attack in the last 6 months
- Cardiovascular or orthopedic issues preventing exercise
- Severe mental illness such as schizophrenia or bipolar disorder
- Current alcohol or drug abuse
- Unable to swallow capsules
- Creatinine clearance (CrCl) less than or equal to 5 mL/min
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lineberger Comprehensive Cancer Center at University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States, 27599
Actively Recruiting
Research Team
A
Ashley M Hanson
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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