Actively Recruiting
MEN-ENDO: Menstrual Stem Cells in Endometriosis
Led by Francisco Algaba Chueca · Updated on 2026-05-11
40
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
F
Francisco Algaba Chueca
Lead Sponsor
H
Hospital Universitari Joan XXIII de Tarragona.
Collaborating Sponsor
AI-Summary
What this Trial Is About
Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterine cavity. It is estimated to affect approximately 10% of women of reproductive age and it is associated with chronic pelvic pain and infertility, among other symptoms. Endometriosis involves complex changes in the body's cells and immune response. For this reason, the goal of this observational study is to characterize the functional, molecular, and immunological alterations in menstrual blood-derived stem cells (MenSCs) and differentiated decidual stromal cells in women with endometriosis; to validate these findings in endometrial tissue and endometriomas; and to establish their correlation with clinical parameters, with the aim of identifying key pathogenic mechanisms and potential therapeutic targets. The main questions it aims to answer are: * Are there functional and molecular changes in MenSCs from patients with endometriosis compared to healthy volunteers? * Are there any variations in the immune properties of MenSCs throughout the menstrual bleeding period in patients with endometriosis compared to healthy volunteers? * Are these changes also present in endometrial tissue and endometrioma samples? * Can these changes be correlated with clinical parameters in patients with endometriosis? * Can MenSCs serve as a potential therapeutic target for endometriosis? Some participants will be asked to provide menstrual blood on a single day, while others will provide samples during the first five days of menstruation. Additionally, all participants will answer questionnaires about their diet, physical activity, stress, and pain levels. Therefore, the study does not involve the evaluation of a specific intervention on the participants. The results will enable the identification of key altered mechanisms and potential therapeutic targets, thereby contributing to the development of more effective strategies for the diagnosis and treatment of the disease.
CONDITIONS
Official Title
MEN-ENDO: Menstrual Stem Cells in Endometriosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 18 to 45 years
- Women diagnosed clinically and/or by imaging with endometriosis
- Women without endometriosis diagnosis (control group)
You will not qualify if you...
- Younger than 18 years or older than 45 years
- Pregnant or breastfeeding
- Diagnosed with chronic pelvic inflammatory or autoimmune disease
- History of active gynecological cancer
- Positive for HIV or HPV infections
- Use of hormonal therapy in the last 3 months
- Use of immunosuppressants or corticosteroids in the last 3 months
- Use of systemic antibiotics in the last 3 months
- Insufficient menstrual flow for stem cell isolation
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut
Reus, Tarragona, Spain, 43201
Active, Not Recruiting
2
Hospital Universitari Joan XXIII
Tarragona, Tarragona, Spain, 43005
Actively Recruiting
Research Team
D
Dr. Francisco Algaba-Chueca
CONTACT
D
Dr. Victoria Linares-Vidal
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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