Actively Recruiting
Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda
Led by University of Rochester · Updated on 2026-01-12
11100
Participants Needed
1
Research Sites
469 weeks
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
L
Lira University
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will investigate the burden, causes, diagnostics, treatments and preventive measures related to meningitis in northern Uganda. We hypothesize that understanding the burden of meningitis, risk factors, diagnostics, treatments and the preventive measures will provide information regarding the gaps in care that can be addressed in order to improve the continuum of meningitis care. we hypothesize that our data will support the advocacy for the implementation of routine vaccination for the prevention of bacterial meningitis and improving guidelines for Cryptococcal antigen (CrAg) screening for prevention of cryptococcal meningitis, which will save lives in Uganda. Aim 1: To prospectively collect data on 1100 patients with meningitis and meningitis symptoms who were admitted to Lira Regional Referral Hospital (LRRH) to assess burden, etiologies, pathogenesis, and outcomes of meningitis using modern diagnostic testing not previously available in Uganda. Aim 2: To perform CrAg screening of 10,000 HIV-positive patients to determine the prevalence of cryptococcal antigenemia (infection) and conduct a case control study to compare risk factors and outcomes among CrAg-positive patients and matched CrAg-negative controls based on age, sex, TB status, ART experience, CD4 count, and viral load.
CONDITIONS
Official Title
Meningitis: Burden, Causes, Screening and Prevention in Rural Northern Uganda
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients of any age presenting with meningitis or meningitis symptoms, eligible for meningitis testing at Lira Regional Referral Hospital
- HIV-positive patients of any age presenting at Lira Regional Referral Hospital, its HIV Clinic, or nearby outpatient clinics, eligible for cryptococcal antigen (CrAg) screening
You will not qualify if you...
- Patients found not to have meningitis after initial evaluation or diagnosed with other conditions explaining symptoms
- HIV-negative patients without signs or symptoms of meningitis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Lira Regional Referral Hospital
Lira, Uganda, 224180000
Actively Recruiting
Research Team
P
Paul Bohjanen, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here