Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06527235

Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography

Led by University Hospital, Toulouse · Updated on 2025-12-04

152

Participants Needed

1

Research Sites

169 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The value of corticosteroid infiltration of the meniscus wall in the therapeutic strategy is not clearly defined: the data in the literature on the effectiveness of corticosteroid infiltration are heterogeneous and of low level of proof. We hypothesize that corticosteroid infiltration of the meniscal wall under ultrasound control would be effective for rapid relief of degenerative meniscal pain. The main objective is to evaluate the efficacy of ultrasound-guided meniscal wall infiltration of betamethasone versus ultrasound-guided meniscal wall infiltration of placebo, at 1 month, on meniscal pain in the treatment of meniscal pain of degenerative origin in adult.

CONDITIONS

Official Title

Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Localized knee pain with tenderness over the medial or lateral joint space confirmed by clinical exam
  • Pain rated higher than 4 out of 10 on a visual analog scale despite first-line analgesics or NSAIDs
  • MRI of the knee performed within the last 6 months
  • Medial or lateral degenerative meniscal lesion on MRI matching the pain and confirmed by a physician
  • Affiliation to Social Security
  • Signed informed consent freely given by the patient
Not Eligible

You will not qualify if you...

  • Under legal guardianship or similar protective status
  • Inability to speak, read, or write French fluently
  • Deprived of liberty
  • Have psychiatric disorders
  • MRI shows unstable meniscal lesions such as complete vertical tears over 10 mm, complex tears, or displaced meniscal fragments
  • Recent ligament injuries shown on MRI
  • Knee trauma within the last 3 months
  • Previous arthroscopy or open surgery on the affected knee
  • Corticosteroid injection in the affected knee within 3 months prior to enrollment
  • Use of NSAIDs or oral corticosteroids within 48 hours before inclusion
  • Use of strong analgesics (tier 3) within 3 months prior to inclusion
  • Episodes of knee instability or locking
  • Radiographic osteoarthritis of grade higher than 1 within last 6 months
  • Known inflammatory rheumatism
  • Diagnosed fibromyalgia
  • Pregnancy or breastfeeding ongoing
  • Contraindications to injectable corticosteroids such as infection, skin lesions at injection site, severe clotting problems, or allergy
  • Contraindications to systemic corticosteroids including acute or uncontrolled infections, psychiatric or eye diseases, uncontrolled diabetes or hypertension
  • Allergy to lidocaine or related local anesthetics
  • Use of anticoagulant medications

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

UHToulouse

Toulouse, France

Actively Recruiting

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Research Team

M

Marie FARUCH, MD

CONTACT

V

Virginie SICART

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

TRIPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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